INT326083

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.66
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCA1) small molecule metabolic process (ABCA1) Golgi apparatus (ABCA1)
ATPase activity (ABCA1) plasma membrane (ABCA1) intracellular (ABCA1)
Anatomy Link Frequency
BFA 2
ABCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 102 97.16 Very High Very High Very High
Disorder Of Lipid Metabolism 42 5.00 Very Low Very Low Very Low
Atherosclerosis 14 5.00 Very Low Very Low Very Low
Cardiovascular Disease 8 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Diabetes Mellitus 2 5.00 Very Low Very Low Very Low
Overweight 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies have shown that apoA-I induces an increase in ABCA1 phosphorylation, as well as an increase in the intracellular levels of cAMP [19], suggesting that the stimulatory effect of apoA-I could be related to cAMP, and thus to PKA [12,13].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of ABCA1
1) Confidence 0.61 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.22 Pain Relevance 0
Certain studies clearly demonstrate that PKA plays a key role in the phosphorylation of ABCA1 that leads to its activation [19], whilst BFA disturbs vesicular traffic as well as the intracellular distribution of ABCA1 [26].
Positive_regulation (leads) of Phosphorylation (phosphorylation) of ABCA1 in BFA
2) Confidence 0.41 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.44 Pain Relevance 0

General Comments

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