INT32611

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.80
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 4.18
Pain Relevance 5.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr)
Anatomy Link Frequency
plasma 3
skeletal muscle 2
astrocytes 2
neurons 1
NIL 1
Insr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 1 98.94 Very High Very High Very High
Eae 3 98.50 Very High Very High Very High
Dorsal horn 2 98.36 Very High Very High Very High
Spinal cord 7 98.04 Very High Very High Very High
Inflammation 4 97.76 Very High Very High Very High
tail-flick 1 95.40 Very High Very High Very High
cocaine 7 94.88 High High
Morphine 20 94.24 High High
hypoalgesia 2 93.88 High High
tolerance 14 92.24 High High
Disease Link Frequency Relevance Heat
Injury 3 98.50 Very High Very High Very High
Diabetes Mellitus 12 98.28 Very High Very High Very High
INFLAMMATION 5 97.76 Very High Very High Very High
Hypoalagesia 2 93.88 High High
Nervous System Injury 2 93.64 High High
Ganglion Cysts 1 90.44 High High
Apoptosis 120 88.84 High High
Hyperalgesia 4 87.36 High High
Obesity 13 86.96 High High
Hyperinsulinism 6 85.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IGF-I (10 nM) inhibited K(+)- as well as veratridine-evoked ACh release from rat hippocampal slices and the effect is possibly mediated via the activation of a typical IGF-I receptor and the subsequent phosphorylation of the insulin receptor substrate-1 (IRS-1).
Phosphorylation (phosphorylation) of insulin receptor
1) Confidence 0.80 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421625 Disease Relevance 0 Pain Relevance 0.52
Western blot analysis revealed decreased phosphorylated: total IR protein ratio that was detectable as early as 2 weeks of diabetes, whereas phosphorylated:total Akt protein ratio was decreased at 2 weeks and increased at 12 weeks of diabetes with unchanged PI-3K protein levels.
Phosphorylation (phosphorylated) of IR protein associated with diabetes mellitus
2) Confidence 0.55 Published 2008 Journal J Pain Section Abstract Doc Link 18331706 Disease Relevance 1.22 Pain Relevance 0.58
In the present study we investigated the influence of dietary sodium on 1) GLUT4 gene expression, by No the n and Western blotting analysis; 2) in vivo GLUT4 protein translocation, by measuring the GLUT4 protein in plasma membrane and microsome, before and after insulin injection; and 3) insulin signaling, by analyzing basal and insulin-stimulated tyrosine phosphorylation of insulin receptor (IR)-beta, insulin receptor substrate (IRS)-1, and IRS-2.
Phosphorylation (phosphorylation) of insulin in plasma
3) Confidence 0.51 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14670806 Disease Relevance 0.15 Pain Relevance 0.08
Compared with NS ats, LS ats showed reduced (P < 0.01) basal and insulin-stimulated tyrosine phosphorylation of IRS-1 in skeletal muscle and IRS-2 in live, whereas HS ats showed enhanced basal tyrosine phosphorylation of IRS-1 in skeletal muscle (P < 0.05) and of IRS-2 in live.
Phosphorylation (phosphorylation) of insulin in skeletal muscle
4) Confidence 0.51 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14670806 Disease Relevance 0.26 Pain Relevance 0.08
In the present study we investigated the influence of dietary sodium on 1) GLUT4 gene expression, by No the n and Western blotting analysis; 2) in vivo GLUT4 protein translocation, by measuring the GLUT4 protein in plasma membrane and microsome, before and after insulin injection; and 3) insulin signaling, by analyzing basal and insulin-stimulated tyrosine phosphorylation of insulin receptor (IR)-beta, insulin receptor substrate (IRS)-1, and IRS-2.
Phosphorylation (phosphorylation) of insulin in plasma
5) Confidence 0.51 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14670806 Disease Relevance 0.15 Pain Relevance 0.09
Beta-endorphin was the major form of IR-BE released by the AP and the sole constituent and secretory product of the NIL.
Phosphorylation (form) of IR-BE in NIL
6) Confidence 0.45 Published 1988 Journal Life Sci. Section Abstract Doc Link 2969443 Disease Relevance 0 Pain Relevance 0.39
Compared with NS ats, LS ats showed reduced (P < 0.01) basal and insulin-stimulated tyrosine phosphorylation of IRS-1 in skeletal muscle and IRS-2 in live, whereas HS ats showed enhanced basal tyrosine phosphorylation of IRS-1 in skeletal muscle (P < 0.05) and of IRS-2 in live.
Phosphorylation (phosphorylation) of insulin in skeletal muscle
7) Confidence 0.39 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14670806 Disease Relevance 0.26 Pain Relevance 0.08
In the present study we investigated the influence of dietary sodium on 1) GLUT4 gene expression, by No the n and Western blotting analysis; 2) in vivo GLUT4 protein translocation, by measuring the GLUT4 protein in plasma membrane and microsome, before and after insulin injection; and 3) insulin signaling, by analyzing basal and insulin-stimulated tyrosine phosphorylation of insulin receptor (IR)-beta, insulin receptor substrate (IRS)-1, and IRS-2.
Phosphorylation (phosphorylation) of insulin in plasma
8) Confidence 0.39 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14670806 Disease Relevance 0.14 Pain Relevance 0.08
Moreover, the increased NR2B-immunoreactivity (IR) and phosphorylated JNK-IR were observed mainly at the superficial dorsal horn laminae of the spinal cord; the spinal p-JNK was mainly expressed in astrocytes and NR2B in neurons.
Phosphorylation (phosphorylated) of IR in astrocytes associated with dorsal horn and spinal cord
9) Confidence 0.37 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19818835 Disease Relevance 0 Pain Relevance 1.45
Peripheral inflammation and chronic constriction injury (CCI) of the sciatic nerve induced a significant increase in the percentage of phosphorylated (P-) p38-immunoreactive (IR) neurons, primarily small sized ones in bilateral DRGs.
Phosphorylation (phosphorylated) of IR in neurons associated with inflammation, eae, injury and sciatic nerve
10) Confidence 0.32 Published 2002 Journal Neuroreport Section Abstract Doc Link 12499853 Disease Relevance 0.95 Pain Relevance 0.71
Moreover, the increased NR2B-immunoreactivity (IR) and phosphorylated JNK-IR were observed mainly at the superficial dorsal horn laminae of the spinal cord; the spinal p-JNK was mainly expressed in astrocytes and NR2B in neurons.
Phosphorylation (phosphorylated) of IR in astrocytes associated with dorsal horn and spinal cord
11) Confidence 0.32 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19818835 Disease Relevance 0 Pain Relevance 1.46
, phosphoinositide 3-kinase (PI3K), phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and phosphorylation of phosphoinositide-dependent kinase-1 (PDK1) (Ser241).
Phosphorylation (phosphorylation) of insulin receptor beta
12) Confidence 0.10 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2712760 Disease Relevance 0.36 Pain Relevance 0.22
Vanadate-sensitive PTPs like PTP-1B inactivate ERK and Akt/PK B indirectly by dephosphorylating upstream growth factor receptors and insulin receptor substrates, thereby preventing tyrosine-dependent docking of molecules like shc, grb2 or PI3-kinase (Neel & Tonks 1997, Elchebly et al. 1999, Galic et al. 2005).
Phosphorylation (dephosphorylating) of insulin receptor
13) Confidence 0.05 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.70 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox