INT326153

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.52
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

CNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 24 81.64 Quite High
Inflammation 29 45.08 Quite Low
COX2 18 12.32 Low Low
cINOD 12 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 338 98.48 Very High Very High Very High
Colon Cancer 373 98.00 Very High Very High Very High
Liver Cancer 6 95.52 Very High Very High Very High
Metastasis 51 95.40 Very High Very High Very High
Mouth Cancer 12 94.16 High High
Recurrence 61 91.84 High High
Breast Cancer 48 89.28 High High
Apoptosis 26 76.40 Quite High
Repression 18 75.20 Quite High
Stress 8 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Within altered chromosomal regions, relations between gene expression and CNA level were assessed by Pearson correlation test (p < 0.01) on genes for which variations (at both level, gene CNA and deregulated expression), were explained by more than 10% of tumors.
Gene_expression (expression) of CNA associated with cancer
1) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.30 Pain Relevance 0
CNA and gene expression have some relationship, but are not linked directly.
Gene_expression (expression) of CNA
2) Confidence 0.01 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2918356 Disease Relevance 0.86 Pain Relevance 0
That means the relationship between CNA and expression is rather weak.
Gene_expression (expression) of CNA
3) Confidence 0.01 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2918356 Disease Relevance 1.04 Pain Relevance 0
To clarify this matter, we need to validate the CNA and expression in detail, as we have planned to do for CXCL6.


Gene_expression (expression) of CNA
4) Confidence 0.01 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2918356 Disease Relevance 1.26 Pain Relevance 0.04
As suggested above, it is important to validate the CNA and/or expression change, but we usually obtain similar results by other methods.
Gene_expression (expression) of CNA
5) Confidence 0.01 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2918356 Disease Relevance 0.82 Pain Relevance 0
When we used a cut-off value of only P < 0.05 for the expression analysis, many genes were extracted, but most of them seemed to be unrelated to either CNA or expression change.
Gene_expression (expression) of CNA
6) Confidence 0.01 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2918356 Disease Relevance 0.45 Pain Relevance 0
Stranger et al found some correlation between SNPs and CNA with the expression levels of the gene in Hapmap samples; however, the overlap of the expression change between SNPs and CNV was small.47 This data suggests that part of the expression change is due to CNV but most of them are related to SNPs.
Gene_expression (expression) of CNA
7) Confidence 0.01 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2918356 Disease Relevance 0.80 Pain Relevance 0

General Comments

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