INT326180

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.38
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Top2a) nuclear chromosome (Top2a) aging (Top2a)
chromosome segregation (Top2a) enzyme binding (Top2a) DNA binding (Top2a)
Top2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 2 96.00 Very High Very High Very High
methotrexate 1 92.00 High High
alcohol 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aggression 1 98.64 Very High Very High Very High
Hepatocellular Cancer 73 98.52 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 1 94.32 High High
Cancer 81 93.72 High High
Recurrence 1 93.48 High High
Breast Cancer 1 87.32 High High
Solid Tumor 1 85.72 High High
Cirrhosis 2 50.84 Quite High
Liver Disease 2 50.28 Quite High
Disease 2 14.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TOP2A over-expression seems to be correlating with the aggressiveness of HCC in terms of early age onset, advanced histological grading, microvascular invasion, chemoresistence, tumor recurrence and mortality [29,30].
Positive_regulation (over) of Gene_expression (expression) of TOP2A associated with cancer, hepatocellular cancer, aggression and recurrence
1) Confidence 0.38 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2918526 Disease Relevance 1.38 Pain Relevance 0.13

General Comments

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