INT326185

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 2
Total Number 14
Disease Relevance 1.46
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
platelet 2
ST7L (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 91 98.28 Very High Very High Very High
agonist 169 97.72 Very High Very High Very High
antagonist 52 95.68 Very High Very High Very High
Inflammation 195 95.48 Very High Very High Very High
Kinase C 13 90.80 High High
bradykinin 13 75.48 Quite High
Catecholamine 13 67.80 Quite High
visual analogue scale 17 62.76 Quite High
imagery 13 55.52 Quite High
Inflammatory response 52 25.00 Low Low
Disease Link Frequency Relevance Heat
Compression Fractures 17 99.26 Very High Very High Very High
INFLAMMATION 247 95.48 Very High Very High Very High
Coagulation Disorder 52 88.88 High High
Malaria 52 83.96 Quite High
Infection 16 80.80 Quite High
Neurologic Manifestations 1 78.20 Quite High
Bites And Stings 65 76.96 Quite High
Hypersensitivity 13 71.28 Quite High
Insect Bites And Stings 13 25.00 Low Low
Erythema 26 24.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
McKiernan et al. defined dynamic mobility of a VCF as any measurable change in VH that occurred between StLR and SuLR.
StLR Binding (occurred) of associated with compression fractures
1) Confidence 0.08 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2918541 Disease Relevance 0.49 Pain Relevance 0.09
Both of these pathways are independent of TXA2, suggesting that the inhibition of collagen-mediated aggregation by AnSt-D7L1 depends only on its ability to bind TXA2.


AnSt-D7L1 Binding (bind) of
2) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0 Pain Relevance 0.17
To determine if AnSt-D7L1 is specific in its binding for CysLTs and TXA2, we screened a number of additional eicosanoid compounds using ITC.
AnSt-D7L1 Binding (binding) of
3) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0 Pain Relevance 0.04
AnSt-D7L1 showed no detectable binding to AA (unpublished data) but bound the prostaglandins PGD2, PGE2, and PGF2?
AnSt-D7L1 Neg (no) Binding (binding) of
4) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0 Pain Relevance 0.04
We find that AnSt-D7L1 has acquired the ability to bind the vasoactive platelet aggregation and proinflammatory agonist TXA2 in addition to maintaining the ability to bind CysLTs.
AnSt-D7L1 Binding (bind) of in platelet associated with agonist
5) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0.08 Pain Relevance 0.05
AeD7 showed no detectable binding with the TXA2 analog U46619, while AnSt-D7L1 binds this ligand with high affinity.
AnSt-D7L1 Binding (binds) of
6) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0.08 Pain Relevance 0.07
Here we have shown that the two-domain D7 protein from An. stephensi, AnSt-D7L1, binds CysLTs like AeD7 but also functions as an inhibitor of platelet activation by binding TXA2.
AnSt-D7L1 Binding (binding) of in platelet
7) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0.08 Pain Relevance 0.08
This result is important in showing that AnSt-D7L1 is able to bind TXA2 itself, since in ITC experiments we were limited to the testing of stable analogues of TXA2.


AnSt-D7L1 Binding (bind) of
8) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0 Pain Relevance 0.12
In this study we demonstrate that AnSt-D7L1, a two-domain member of this group from Anopheles stephensi, retains the CysLT binding function seen in the homolog AeD7 from Aedes aegypti but has lost the ability to bind biogenic amines.
AnSt-D7L1 Binding (bind) of
9) Confidence 0.01 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2994686 Disease Relevance 0.43 Pain Relevance 0.09
This suggests that mosquito salivary secretions contain D7 protein forms that bind both CysLTs and TXA2, as well as forms that bind only CysLTs, and that there may be an adaptive significance to differences in TXA2 binding observed in AeD7 and AnSt-D7L1.


AnSt-D7L1 Binding (binding) of
10) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0.22 Pain Relevance 0.03
Rather than binding in the separate domains of AnSt-D7L1, both ligands were found to bind in the hydrophobic pocket of the N-terminal domain of the protein.
AnSt-D7L1 Binding (binding) of
11) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0 Pain Relevance 0.03
AnSt-D7L1 did not bind LTB4, a ligand previously shown to bind with AeD7 [15] with low affinity (unpublished data).


AnSt-D7L1 Neg (not) Binding (bind) of
12) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0.08 Pain Relevance 0.11
AnSt-D7L1 showed no detectable binding to AA (unpublished data) but bound the prostaglandins PGD2, PGE2, and PGF2?
AnSt-D7L1 Binding (bound) of
13) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0 Pain Relevance 0.04
AnSt-D7L1 showed no detectable binding of biogenic amines, however, suggesting that its C-terminal domain is structurally distinct from the comparable, biogenic amine-binding C-terminal domain of AeD7 (unpublished data).
AnSt-D7L1 Neg (no) Binding (binding) of
14) Confidence 0.01 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2994686 Disease Relevance 0 Pain Relevance 0.05

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