INT326193

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.11
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) extracellular space (Car2) lyase activity (Car2)
extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf) cytoplasm (Car2)
Anatomy Link Frequency
growth cone 2
neurons 1
Bdnf (Mus musculus)
Car2 (Mus musculus)
Pain Link Frequency Relevance Heat
bDMF 91 100.00 Very High Very High Very High
Calcium channel 4 99.36 Very High Very High Very High
imagery 5 62.24 Quite High
Spinal cord 8 56.08 Quite High
Eae 50 53.16 Quite High
central sensitization 16 50.00 Quite Low
Dorsal horn neuron 3 50.00 Quite Low
Peripheral nerve injury 3 44.16 Quite Low
cytokine 7 29.56 Quite Low
midbrain 1 8.00 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 21 60.96 Quite High
Injury 55 53.16 Quite High
Nervous System Injury 5 44.16 Quite Low
Confusion 4 24.84 Low Low
Nociception 2 11.20 Low Low
Neuropathic Pain 12 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The TRPC3/6 calcium channels have been shown to mediate the BDNF-induced elevation of Ca2+ in rat cerebellar granule cell cultures and to be required for the nerve-growth cone turning induced by BDNF in these cells [11].
BDNF Positive_regulation (elevation) of Ca2 in growth cone associated with calcium channel
1) Confidence 0.14 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0 Pain Relevance 0.05
TRPC channels, in particular TRPC3/6, mediated the BDNF-induced elevation of Ca2+ in these cells, and were required for the nerve-growth cone turning induced by BDNF [11].
BDNF Positive_regulation (elevation) of Ca2 in growth cone
2) Confidence 0.14 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2964534 Disease Relevance 0.06 Pain Relevance 0
The summary of responses of larger populations of neurons illustrated in Figure 2E shows that 200 ng/ml BDNF, but not 50 ng/ml, significantly increased the Ca2+ responses (Figure 2E).
BDNF Positive_regulation (increased) of Ca2 in neurons associated with bdmf
3) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2918544 Disease Relevance 0.05 Pain Relevance 0.57

General Comments

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