INT326194

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.85
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc12a5) extracellular region (Bdnf) plasma membrane (Slc12a5)
intracellular (Slc12a5) cytoplasmic membrane-bounded vesicle (Bdnf) transmembrane transport (Slc12a5)
Anatomy Link Frequency
neurons 1
Bdnf (Mus musculus)
Slc12a5 (Mus musculus)
Pain Link Frequency Relevance Heat
bDMF 91 100.00 Very High Very High Very High
gABA 3 99.40 Very High Very High Very High
central sensitization 16 95.64 Very High Very High Very High
allodynia 4 91.08 High High
Neurotransmitter 2 90.36 High High
Dorsal horn neuron 3 86.68 High High
Eae 46 83.12 Quite High
GABAergic 1 80.92 Quite High
Peripheral nerve injury 3 80.08 Quite High
intrathecal 2 75.04 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 12 91.08 High High
Injury 55 83.12 Quite High
Nervous System Injury 5 80.08 Quite High
Pain 6 73.84 Quite High
Targeted Disruption 1 72.88 Quite High
Hyperalgesia 4 68.88 Quite High
INFLAMMATION 1 66.52 Quite High
Nociception 2 53.08 Quite High
Necrosis 2 11.28 Low Low
Cancer 2 10.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mechanistically, this is thought to involve alterations in GABA release [33] as well as down regulation of the chloride transporter KCC2 in lamina 1 neurons by microglial-derived BDNF [14,86].
BDNF Regulation (regulation) of KCC2 in neurons associated with gaba and bdmf
1) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2918544 Disease Relevance 0.85 Pain Relevance 1.35

General Comments

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