INT32623

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Context Info
Confidence 0.43
First Reported 1983
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 10.96
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
blood 2
plasma 2
fat 2
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 7 100.00 Very High Very High Very High
anesthesia 27 99.84 Very High Very High Very High
cytokine 26 99.82 Very High Very High Very High
Inflammation 29 99.60 Very High Very High Very High
Enkephalin 5 99.44 Very High Very High Very High
isoflurane 3 99.20 Very High Very High Very High
antagonist 8 99.12 Very High Very High Very High
Somatostatin 4 98.76 Very High Very High Very High
ischemia 4 98.32 Very High Very High Very High
Angina 34 96.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 43 99.60 Very High Very High Very High
Diabetes Mellitus 196 99.56 Very High Very High Very High
Weight Loss 11 99.32 Very High Very High Very High
Anxiety Disorder 4 99.32 Very High Very High Very High
Stress 41 99.26 Very High Very High Very High
Coronary Artery Disease 96 98.76 Very High Very High Very High
Adrenal Cancer 138 98.48 Very High Very High Very High
Hyperinsulinism 22 97.90 Very High Very High Very High
Polycystic Ovary Syndrome 109 97.74 Very High Very High Very High
Obesity 126 97.10 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Obese subjects displayed an increased insulin response to oral and i.v. glucose load, due to an increased first phase of insulin secretion (phi 1), a reduced insulin sensitivity (Si) and glucose effectiveness (Sg) in respect to normal-weight subjects.
Negative_regulation (reduced) of Regulation (sensitivity) of insulin associated with obesity and hyperinsulinism
1) Confidence 0.43 Published 1994 Journal Horm. Metab. Res. Section Abstract Doc Link 8082873 Disease Relevance 0.42 Pain Relevance 0.34
In the enkephalin analogue treated subjects, diminished insulin response to glucose was observed following the oral glucose load, with insulin values significantly lower than in the controls from time 10 to 90 min, but no corresponding change in the glucose curve.
Negative_regulation (diminished) of Regulation (response) of insulin associated with enkephalin
2) Confidence 0.43 Published 1983 Journal Acta Endocrinol. Section Abstract Doc Link 6353831 Disease Relevance 0.29 Pain Relevance 0.47
Insulin sensitivity was greatly impaired by anesthesia with isoflurane, but was not affected by use of the anxiolytic agent diazepam.
Negative_regulation (impaired) of Regulation (sensitivity) of Insulin associated with anesthesia, anxiety disorder and isoflurane
3) Confidence 0.43 Published 2003 Journal Comp. Med. Section Abstract Doc Link 12625507 Disease Relevance 1.27 Pain Relevance 0.24
Insulin sensitivity decreased by 75% in diabetics (groups D, DD, DDA), compared with animals of groups C and H, and was inversely related to fasting blood glucose concentration (r = -0.72).
Negative_regulation (decreased) of Regulation (sensitivity) of Insulin in blood associated with diabetes mellitus
4) Confidence 0.43 Published 2003 Journal Comp. Med. Section Abstract Doc Link 12625507 Disease Relevance 1.16 Pain Relevance 0.23
Insulin acted at the insulin receptor via pathways dependent on tyrosine kinase and phosphatidylinositol 3 kinase because the insulin effect was eliminated by the insulin receptor antagonist, hydroxy-2-naphthalenylmethylphosphonic acid trisacetoxymethyl ester, the tyrosine kinase inhibitor lavendustin A, and the phosphatidylinositol 3 kinase antagonist wortmannin.
Negative_regulation (eliminated) of Regulation (effect) of insulin associated with antagonist
5) Confidence 0.41 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17308032 Disease Relevance 0.06 Pain Relevance 0.23
In patients with PCOS, the level of PAI-1 was found to be elevated (Atiomo et al 1998; Sampson et al 1996; Yildiz et al 2002), and it decreased with improvement in insulin sensitivity, either through weight loss (Andersen et al 1995) or the use of insulin sensitizing agents (Ehrmann et al 1997; Velazquez et al 1997).
Negative_regulation (decreased) of Regulation (sensitivity) of insulin associated with weight loss and polycystic ovary syndrome
6) Confidence 0.40 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994046 Disease Relevance 1.32 Pain Relevance 0
The postoperative responses of plasma glucagon and insulin were not impaired compared with their preoperative responses.
Negative_regulation (impaired) of Regulation (responses) of insulin in plasma
7) Confidence 0.39 Published 1987 Journal Jpn J Surg Section Abstract Doc Link 3553685 Disease Relevance 0.37 Pain Relevance 0.14
Acute insulin and C-peptide responses to intravenous pulses of different glucose amounts (0.33 g/kg and 5 g) and arginine (3 g) were significantly reduced by beta-endorphin infusion (P less than .01).
Negative_regulation (reduced) of Regulation (responses) of insulin
8) Confidence 0.36 Published 1988 Journal Diabetes Section Abstract Doc Link 2970411 Disease Relevance 0 Pain Relevance 0
Major mediators are the previously mentioned catabolic hormones and cytokines and the reduced anabolic influence of growth hormone, insulin, and testosterone [18,19].
Negative_regulation (reduced) of Regulation (influence) of insulin associated with cytokine
9) Confidence 0.32 Published 2008 Journal Crit Care Section Body Doc Link PMC2575562 Disease Relevance 0.68 Pain Relevance 0.05
Subjects bearing PC-1

Lys121Gln variant show higher levels of fasting glucose and decreased insulin sensitivity on Pro12 background, whereas this effect of PC-1 Lys121Gln variant is lost on Ala12 background [113].

Negative_regulation (decreased) of Regulation (sensitivity) of insulin
10) Confidence 0.22 Published 2009 Journal PPAR Research Section Body Doc Link PMC2669649 Disease Relevance 0.34 Pain Relevance 0.03
Administration of a marcronutrient, causes a shift towards oxidative stress and inflammation, which in turn may reduce insulin sensitivity.
Negative_regulation (reduce) of Regulation (sensitivity) of insulin associated with stress and inflammation
11) Confidence 0.14 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2910415 Disease Relevance 1.12 Pain Relevance 0.19
An infusion of amino acids in rats caused a decrease in IGFBP-1 without any changes in insulin [48].
Negative_regulation (decrease) of Neg (without) Regulation (changes) of insulin
12) Confidence 0.12 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC1779788 Disease Relevance 0.07 Pain Relevance 0
Using the minimal model to assess insulin sensitivity, insulin sensitivity was found to be decreased in six untreated nonobese women with NCAH compared to control subjects [76].
Negative_regulation (decreased) of Regulation (sensitivity) of insulin associated with adrenal cancer
13) Confidence 0.10 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2910408 Disease Relevance 1.49 Pain Relevance 0.07
Most studies comparing F and S have shown that both sugars behave in essentially similar manners, pointing to the fact that F is actually the culprit.94–97 No differences in energy balance were found between HFCS, S and milk.98 When compared to G, HFCS and S always lead to higher TG or glucose/insulin responses over a 24-h period.99 In a study investigating the effects of 34% F in 3 different diets (F, F+G and S), a reduction in insulin sensitivity in rats was observed in every regimen.97 Several studies have compared F and G, and in a one-week study, F increased VLDL more than G, but intramuscular lipids were higher with G.100 Essentially the same qualitative difference was found in another study that extended the comparison to one month.96 Giving sweetened beverages to overweight or obese subjects for up to 10 weeks showed that F but not G increased lipid synthesis and visceral adiposity and reduced insulin sensitivity; G administration led to increased subcutaneous fat, which is relatively harmless.101 When F or G was administered with meals, obese patients showed lower insulin and leptin levels but increased postprandial TGs; HTG lasted for over 24 hours in the insulin-resistant subgroup.12
Negative_regulation (reduction) of Regulation (sensitivity) of insulin in fat associated with obesity and overweight
14) Confidence 0.08 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2910863 Disease Relevance 0.25 Pain Relevance 0
A factor related to the diabetic condition (unbalanced glucose levels, defective insulin regulation, etc) in cooperation with the myocardial ischemia could be responsible for the high levels of VEGF and bFGF observed in the diabetic patients (CAD SA).
Negative_regulation (defective) of Regulation (regulation) of insulin associated with coronary artery disease, diabetes mellitus and ischemia
15) Confidence 0.05 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.61 Pain Relevance 0.23
The effect of substance P on insulin, glucagon, and exocrine secretion was blocked by the NK-1 receptor antagonist.
Negative_regulation (blocked) of Regulation (effect) of insulin associated with antagonist and substance p
16) Confidence 0.05 Published 2000 Journal Pancreas Section Abstract Doc Link 10766449 Disease Relevance 0 Pain Relevance 0.67

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