INT326248

Context Info Confidence 0.00 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.62 Pain Relevance 0.13

mitochondrion (Prkaca) Golgi apparatus (Prkaca) plasma membrane (Prkaca) nucleus (Prkaca) protein complex (Prkaca) kinase activity (Prkaca)

Prkaca (Mus musculus) ras (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 6 99.76 Neuropathic pain 1 48.52 Migraine 1 47.68 Immobilon 1 5.00

Disease Link Frequency Relevance Heat Cancer 12 81.76 Apoptosis 2 71.84 Myelodysplastic Syndromes 1 63.84 Leukemia 1 62.76 Metastasis 1 53.76 Neuropathic Pain 1 48.52 Headache 1 47.68 Manic Depressive Disorder 1 47.28 Epilepsy 2 44.84 Glioma 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Erk1/2 can also be activated Ras-independently by other upstream molecules, including protein kinase A (PKA) and PKC.

PKA Neg (independently) Positive_regulation (activated) of Ras associated with kinase c

1) Confidence 0.00 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.62 Pain Relevance 0.13

General Comments

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