INT32625

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Context Info
Confidence 0.49
First Reported 1988
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 1.39
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Uchl1) intracellular (Uchl1) ligase activity (Uchl1)
response to stress (Uchl1) cytoplasm (Uchl1) cell proliferation (Uchl1)
Anatomy Link Frequency
medulla 3
T cells 1
Uchl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 3 98.74 Very High Very High Very High
medulla 9 98.24 Very High Very High Very High
Rostral ventrolateral medulla 18 96.48 Very High Very High Very High
Inflammation 1 77.60 Quite High
spinal inflammation 1 74.80 Quite High
Arthritis 1 70.24 Quite High
depression 3 34.48 Quite Low
Disease Link Frequency Relevance Heat
Poisoning 9 99.76 Very High Very High Very High
Toxicity 3 95.04 Very High Very High Very High
Disease 1 83.68 Quite High
INFLAMMATION 1 77.60 Quite High
Arthropathy 1 76.56 Quite High
Ankylosing Spondylitis 1 75.04 Quite High
Synovitis 2 75.00 Quite High
Syndrome 1 72.16 Quite High
Seronegative Spondarthritis 1 71.04 Quite High
Pressure Volume 2 Under Development 3 56.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Sprague-Dawley rats maintained under propofol anesthesia, Mev (960 microg/kg, i.v.) induced a parallel and progressive augmentation in UCH-L1 or ubiquitin expression at the ventrolateral medulla during the course of Mev intoxication.
Positive_regulation (augmentation) of UCH-L1 in medulla associated with medulla, anesthesia and poisoning
1) Confidence 0.49 Published 2004 Journal Shock Section Abstract Doc Link 15545831 Disease Relevance 0.27 Pain Relevance 0.42
In Sprague-Dawley rats maintained under propofol anesthesia, Mev (960 microg/kg, i.v.) induced a parallel and progressive augmentation in UCH-L1 or ubiquitin expression at the ventrolateral medulla during the course of Mev intoxication.
Positive_regulation (augmentation) of UCH-L1 in medulla associated with medulla, anesthesia and poisoning
2) Confidence 0.49 Published 2004 Journal Shock Section Abstract Doc Link 15545831 Disease Relevance 0.27 Pain Relevance 0.42
The increase in UCH-L1 level was significantly blunted on pretreatment with bilateral microinjection into the RVLM of a transcription inhibitor, actinomycin D (5 nmol), or a translation inhibitor, cycloheximide (20 nmol).
Positive_regulation (increase) of UCH-L1 in RVLM associated with rostral ventrolateral medulla
3) Confidence 0.40 Published 2004 Journal Shock Section Abstract Doc Link 15545831 Disease Relevance 0.32 Pain Relevance 0.42
We have previously shown that rheumatoid synovial T cells are virtually all helper-inducer (CD4+4B4+UCHL1+) rather than suppressor-inducer (CD4+2H4+) cells.
Positive_regulation (helper-inducer) of UCHL1 in T cells
4) Confidence 0.28 Published 1988 Journal Scand. J. Immunol. Section Abstract Doc Link 2970668 Disease Relevance 0.53 Pain Relevance 0.15

General Comments

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