INT326310

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.50
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

H19 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 2 58.32 Quite High
anesthesia 3 36.12 Quite Low
ketamine 3 13.64 Low Low
positron emission tomography 6 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diphtheria 26 98.76 Very High Very High Very High
Cancer 237 97.32 Very High Very High Very High
Ovarian Cancer 30 94.64 High High
Pancreatic Cancer 96 92.20 High High
Toxicity 11 91.48 High High
Pressure And Volume Under Development 56 87.36 High High
Disease 21 82.72 Quite High
Hypoxia 12 81.68 Quite High
Starvation 6 80.00 Quite High
Metastasis 53 64.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We constructed a plasmid in which the expression of DT-A is controlled by the transcriptional regulatory sequences of the H19 gene (DTA-H19).
Regulation (controlled) of Gene_expression (sequences) of H19 gene
1) Confidence 0.45 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2918631 Disease Relevance 0.78 Pain Relevance 0.03
Since there is no report of the hamster's H19 gene sequence at the gene databases Ensembl and NCBI, primers designed originally for human and murine known H19 sequence were tested to determine H19 RNA level in hamster PC.1-0 cells.
Spec (determine) Regulation (determine) of Spec (determine) Gene_expression (level) of H19
2) Confidence 0.44 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.68 Pain Relevance 0
We constructed a plasmid in which the expression of DT-A is controlled by the transcriptional regulatory sequences of the H19 gene (DTA-H19).
Regulation (controlled) of Gene_expression (sequences) of DTA-H19
3) Confidence 0.39 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2918631 Disease Relevance 0.79 Pain Relevance 0.03
The effect of the DTA-H19 plasmid cotransfected into cells with a second plasmid which encodes the luciferase gene under the control of the SV40 regulatory sequence caused inhibition of the luciferase activity at a dose-response manner in all the studied cell lines (Figure 3).
Regulation (effect) of Gene_expression (cotransfected) of H19
4) Confidence 0.26 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.74 Pain Relevance 0
Therefore, the observed effect is more likely due to the cytotoxic effect of the DTA-H19 plasmid expression and not the result of competition between the two plasmids for the entry into the cell.
Regulation (effect) of Gene_expression (expression) of H19
5) Confidence 0.23 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.52 Pain Relevance 0

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