INT326387

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.59
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PROC, Rhoa) cell differentiation (Rhoa) mitochondrion (Rhoa)
cell morphogenesis (Rhoa) intracellular (Rhoa) GTPase activity (Rhoa)
Anatomy Link Frequency
brain 3
Neural 2
PROC (Homo sapiens)
Rhoa (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 10 63.52 Quite High
cerebral cortex 30 52.60 Quite High
Hippocampus 55 25.84 Quite Low
Thalamus 25 25.76 Quite Low
interneuron 5 22.96 Low Low
Pyramidal cell 5 9.04 Low Low
midbrain 5 5.00 Very Low Very Low Very Low
Peripheral nervous system 5 5.00 Very Low Very Low Very Low
Neuritis 5 5.00 Very Low Very Low Very Low
halothane 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 80 88.92 High High
Fasciculation 65 88.64 High High
Neuritis 5 5.00 Very Low Very Low Very Low
Hypothermia 5 5.00 Very Low Very Low Very Low
Cancer 5 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 5 5.00 Very Low Very Low Very Low
Stroke 5 5.00 Very Low Very Low Very Low
Anuria 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Co-immunoprecipation analyses in brain lysates revealed that neural PC also interacts with RhoA and with the related small GTPase RhoG (Fig. 2h,i).
PC Binding (interacts) of RhoA in neural
1) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0 Pain Relevance 0
In the present study, we found that brain PC interacts with the Ezrin/NHERF1-2/RhoA-G complex, thereby suggesting that activation of this protein complex is responsible for the reduction in neurite growth and branching observed in PC loss-of-function models.
PC Binding (complex) of RhoA in brain
2) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0.17 Pain Relevance 0.06
Brain PC forms a protein complex with Ezrin, NHERF1/2 and RhoA/G
PC Binding (complex) of RhoA in Brain
3) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0 Pain Relevance 0
In the present study, we found that brain PC interacts with the Ezrin/NHERF1-2/RhoA-G complex, thereby suggesting that activation of this protein complex is responsible for the reduction in neurite growth and branching observed in PC loss-of-function models.
PC Binding (interacts) of RhoA in brain
4) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0.17 Pain Relevance 0.06
Neural PC interacts with the ERM protein family, and with NHERF1/2 and RhoA/G.
PC Binding (interacts) of RhoA in Neural
5) Confidence 0.00 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2919383 Disease Relevance 0.25 Pain Relevance 0

General Comments

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