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Context Info
Confidence 0.46
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.17
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mc2r) plasma membrane (Mc2r) signal transducer activity (Mc2r)
Anatomy Link Frequency
immune cell 1
pituitary 1
anterior pituitary 1
Mc2r (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 3 99.90 Very High Very High Very High
Neuropeptide 2 99.82 Very High Very High Very High
opioid receptor 5 99.34 Very High Very High Very High
Central nervous system 1 98.78 Very High Very High Very High
aspirin 1 93.60 High High
Kappa opioid receptor 1 92.64 High High
cINOD 1 91.44 High High
Opioid 3 90.72 High High
Endogenous opioid 2 87.76 High High
Dopamine 1 84.84 Quite High
Disease Link Frequency Relevance Heat
Fever 1 99.74 Very High Very High Very High
Stress 17 99.54 Very High Very High Very High
Infection 3 98.48 Very High Very High Very High
Appetite Loss 1 98.16 Very High Very High Very High
Pituitary Cancer 1 95.16 Very High Very High Very High
INFLAMMATION 1 91.04 High High
Targeted Disruption 8 87.76 High High
Cancer 1 81.84 Quite High
Alcohol Addiction 1 81.36 Quite High
Depression 1 78.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our study assessed the contribution of opioid receptors in stress-induced analgesia and adrenocorticotropic hormone (ACTH) and corticosterone release by a genetic approach.
Localization (release) of adrenocorticotropic hormone associated with stress, opioid receptor and analgesia
1) Confidence 0.46 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16237385 Disease Relevance 0.79 Pain Relevance 0.76
A systemic infection in patients causes so-called sickness behaviors, such as fever generation, adrenocorticotropic hormone release, reduced locomotion, loss of social contact, anorexia, and increased sleep.
Localization (release) of adrenocorticotropic hormone associated with appetite loss, fever and infection
2) Confidence 0.22 Published 2008 Journal J. Infect. Chemother. Section Abstract Doc Link 18709530 Disease Relevance 0.46 Pain Relevance 0.14
The basal secretion of adrenocorticotropin (ACTH) as well as the corticotropin-releasing factor (CRF)-stimulated ACTH released remained unchanged after R(+)- and S(-)-SAL treatment.
Localization (secretion) of adrenocorticotropin
3) Confidence 0.17 Published 1995 Journal Alcohol Section Abstract Doc Link 8519440 Disease Relevance 0.18 Pain Relevance 0.32
Numerous studies have demonstrated the role of the central nervous system in immunomodulation. beta-Endorphin, a neuropeptide that is released along with adrenocorticotropin by the pituitary in response to stress, has been shown to have various effects on immune function, although these effects are dependent on dose, animal model, and immune cell tested.
Localization (released) of adrenocorticotropin in immune cell associated with stress, neuropeptide and central nervous system
4) Confidence 0.16 Published 1988 Journal Mech. Ageing Dev. Section Abstract Doc Link 2971843 Disease Relevance 0.34 Pain Relevance 0.10
Corticotropin-releasing hormone (CRH) mainly regulates the synthesis and secretion of adrenocorticotropin (ACTH) in the anterior pituitary (AP).
Localization (secretion) of adrenocorticotropin in anterior pituitary
5) Confidence 0.13 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15331153 Disease Relevance 0.14 Pain Relevance 0.07
In times of stress the hypothalamic-pituitary-adrenal (HPA) axis is activated and releases two neurohormones, corticotropin-releasing hormone (Crh) and arginine vasopressin (Avp), to synergistically stimulate the secretion of adrenocorticotropin hormone (ACTH) from the anterior pituitary, culminating in a rise in circulating glucocorticoids.
Localization (secretion) of adrenocorticotropin hormone in pituitary associated with stress
6) Confidence 0.12 Published 2008 Journal Psychoneuroendocrinology Section Abstract Doc Link 18243568 Disease Relevance 0.26 Pain Relevance 0.21

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