INT326390

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 1.00
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PROC, Ezr) intracellular (Ezr) cytoplasm (Ezr)
cytoskeletal protein binding (Ezr) cytosol (Ezr) extracellular space (PROC)
Anatomy Link Frequency
brain 3
podocytes 2
kidney 2
MDCK 1
PROC (Homo sapiens)
Ezr (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 16 63.52 Quite High
cerebral cortex 48 59.36 Quite High
interneuron 8 29.72 Quite Low
Hippocampus 88 25.84 Quite Low
Pyramidal cell 8 9.04 Low Low
Thalamus 40 5.00 Very Low Very Low Very Low
midbrain 8 5.00 Very Low Very Low Very Low
Peripheral nervous system 8 5.00 Very Low Very Low Very Low
Neuritis 8 5.00 Very Low Very Low Very Low
halothane 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 128 90.12 High High
Cancer 8 86.16 High High
Fasciculation 104 83.92 Quite High
Anuria 8 81.12 Quite High
Neuritis 8 5.00 Very Low Very Low Very Low
Hypothermia 8 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 8 5.00 Very Low Very Low Very Low
Stroke 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Brain PC forms a protein complex with Ezrin, NHERF1/2 and RhoA/G
PC Binding (complex) of Ezrin in Brain
1) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0 Pain Relevance 0
In kidney and MDCK cells, PC interacts with Ezrin and the sodium-hydrogen exchanger regulatory factor 1 and 2 (NHERF1/2) [25], [33], [34].
PC Binding (interacts) of Ezrin in kidney
2) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0 Pain Relevance 0
Two cytosolic adaptor proteins, Na+/H+-Exchanger Regulatory Factor 2 (NHERF2) and Ezrin, interact with PC in kidney [25].
PC Binding (interact) of Ezrin in kidney
3) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0.34 Pain Relevance 0
In the present study, we found that brain PC interacts with the Ezrin/NHERF1-2/RhoA-G complex, thereby suggesting that activation of this protein complex is responsible for the reduction in neurite growth and branching observed in PC loss-of-function models.
PC Binding (complex) of Ezrin in brain
4) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0.17 Pain Relevance 0.06
In kidney podocytes PC forms a complex with Ezrin and the NHERF2, which promotes RhoA activation and stabilizes the actin cytoskeleton [25], [34].
PC Binding (forms) of Ezrin in podocytes
5) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0.16 Pain Relevance 0.03
In the present study, we found that brain PC interacts with the Ezrin/NHERF1-2/RhoA-G complex, thereby suggesting that activation of this protein complex is responsible for the reduction in neurite growth and branching observed in PC loss-of-function models.
PC Binding (interacts) of Ezrin in brain
6) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0.17 Pain Relevance 0.06
In kidney podocytes PC forms a complex with Ezrin and the NHERF2, which promotes RhoA activation and stabilizes the actin cytoskeleton [25], [34].
PC Binding (complex) of Ezrin in podocytes
7) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0.16 Pain Relevance 0.03
In kidney and MDCK cells, PC interacts with Ezrin and the sodium-hydrogen exchanger regulatory factor 1 and 2 (NHERF1/2) [25], [33], [34].
PC Binding (interacts) of Ezrin in MDCK
8) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919383 Disease Relevance 0 Pain Relevance 0

General Comments

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