INT326426

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.32 Pain Relevance 0

mRNA processing (Ddx41) RNA binding (Ddx41) nucleus (Ddx41) helicase activity (Ddx41) biological_process (Ddx41)

Ddx41 (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 2 5.00 Inflammation 2 5.00 Central nervous system 1 5.00 ketamine 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Infection 86 93.40 Disease 4 68.08 African Trypanosomiasis 3 50.00 Congenital Anomalies 2 29.52 Parasitemia 13 5.00 Anaemia 4 5.00 Hypergammaglobulinemia 4 5.00 Hematological Disease 4 5.00 Death 3 5.00 Thrombocytopenia 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The inability of infected individuals to produce long-lasting amounts of antigen-specific IgG Abs and the levels of antigenic variation displayed by the parasites impose major difficulties that prevent immune intervention against trypanosomosis.

Negative_regulation (amounts) of Abs

1) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919407 Disease Relevance 0.32 Pain Relevance 0

General Comments

This test has worked.