INT326428

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 0.75
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Eif2ak2) nucleus (Eif2ak2) intracellular (Eif2ak2)
translation (Eif2ak2) kinase activity (Eif2ak2)
Anatomy Link Frequency
B cells 2
fibroblasts 2
Eif2ak2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 27 96.04 Very High Very High Very High
Inflammation 42 95.64 Very High Very High Very High
tolerance 210 78.00 Quite High
addiction 5 75.88 Quite High
palliative 5 25.96 Quite Low
agonist 15 5.00 Very Low Very Low Very Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 47 95.64 Very High Very High Very High
Stress 5 91.84 High High
Infection 111 89.68 High High
Parasitemia 13 74.64 Quite High
Thrombocytopenia 3 73.08 Quite High
Apoptosis 2 56.40 Quite High
African Trypanosomiasis 3 50.00 Quite Low
Targeted Disruption 15 43.44 Quite Low
Hypergammaglobulinemia 4 43.40 Quite Low
Sepsis 50 38.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test this hypothesis, PKR was overexpressed in HEK293T cells, along with increasing concentrations of a SOCS-1 expression vector.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of PKR
1) Confidence 0.32 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.06 Pain Relevance 0.14
V5-tagged wild-type (WT) PKR was overexpressed in HEK293T cells, along with expression vectors for WT hemagglutinin (HA)-tagged ubiquitin (HA-Ub) or HA-tagged ubiquitin bearing a single lysine at either position 48 or 63 (HA-K48 only or HA-K63 only).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of PKR
2) Confidence 0.32 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0 Pain Relevance 0.03
V5-tagged WT PKR was transfected into HEK293T cells without or with concomitant transfection of FLAG-tagged SOCS-1, and immunoprecipitations were carried out with anti-FLAG monoclonal antibody.
Positive_regulation (transfected) of Neg (without) Gene_expression (transfected) of PKR
3) Confidence 0.23 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0 Pain Relevance 0
We also show that total PKR levels are elevated in LPS-tolerant murine macrophages but not in MEFs, a fact that may reflect the far greater LPS sensitivity of macrophages compared to that of embryonic fibroblasts.
Positive_regulation (elevated) of Gene_expression (levels) of PKR in fibroblasts
4) Confidence 0.23 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.09 Pain Relevance 0.16
Importantly, SOCS-2 overexpression had a negligible effect on the basal level of PKR, even at the highest dose (Fig. 5C).
Positive_regulation (overexpression) of Gene_expression (overexpression) of PKR
5) Confidence 0.23 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0 Pain Relevance 0
It is also possible that CpG-DNA motifs released from the parasite may trigger the production of IFN type I, lead to the intense activation of B cells and equally contribute to the expression of Sca-1 by bone marrow cells [32]–[34].
Positive_regulation (trigger) of Gene_expression (production) of IFN type I in B cells
6) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919407 Disease Relevance 0.60 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox