INT326456

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.11
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx1, Pip4k2b) endoplasmic reticulum (Pip4k2b) plasma membrane (Pip4k2b)
DNA binding (Runx1) kinase activity (Pip4k2b) transcription factor binding (Runx1)
Anatomy Link Frequency
nociceptors 1
Runx1 (Mus musculus)
Pip4k2b (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 79 96.48 Very High Very High Very High
Inflammation 14 53.20 Quite High
Neuropathic pain 35 51.84 Quite High
IPN 19 25.08 Quite Low
withdrawal 6 13.92 Low Low
Pain 17 5.00 Very Low Very Low Very Low
allodynia 8 5.00 Very Low Very Low Very Low
Hyperalgesia 7 5.00 Very Low Very Low Very Low
Lasting pain 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 14 53.20 Quite High
Neuropathic Pain 44 51.84 Quite High
Inflammatory Pain 19 25.08 Quite Low
Pain 20 5.00 Very Low Very Low Very Low
Targeted Disruption 14 5.00 Very Low Very Low Very Low
Hyperalgesia 7 5.00 Very Low Very Low Very Low
Nervous System Injury 6 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 5 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low
Hypersensitivity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mechanistically, we reported previously that Runx1 switches from an activator at early stages to a repressor at postnatal stages in regulating Mrgpra3, b4, and c11 [24], thereby explaining why their expression can only be sustained in Runx1-transient nociceptors.
Runx1 Regulation (regulating) of c11 in nociceptors associated with nociceptor
1) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.11 Pain Relevance 0.71

General Comments

This test has worked.

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