INT32648

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Context Info
Confidence 0.66
First Reported 1987
Last Reported 2010
Negated 2
Speculated 7
Reported most in Abstract
Documents 80
Total Number 89
Disease Relevance 17.90
Pain Relevance 16.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyrp1) oxidoreductase activity (Tyrp1)
Anatomy Link Frequency
plasma 13
macrophage 3
brain 3
hippocampus 3
sensory neurons 3
Tyrp1 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 1254 100.00 Very High Very High Very High
Serotonin 119 100.00 Very High Very High Very High
melanocortin 1 receptor 68 100.00 Very High Very High Very High
member 8 4 99.72 Very High Very High Very High
antagonist 23 99.58 Very High Very High Very High
Root ganglion neuron 8 99.56 Very High Very High Very High
Pain 71 99.32 Very High Very High Very High
Hippocampus 338 99.00 Very High Very High Very High
Spinal cord 16 99.00 Very High Very High Very High
spastic colon 14 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Microphthalmia 13 100.00 Very High Very High Very High
Nociception 24 99.84 Very High Very High Very High
INFLAMMATION 64 99.64 Very High Very High Very High
Sprains And Strains 428 99.52 Very High Very High Very High
Ganglion Cysts 274 99.36 Very High Very High Very High
Pain 65 99.32 Very High Very High Very High
Disease 112 99.20 Very High Very High Very High
Bacterial Respiratory Disease 15 99.04 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

11 98.88 Very High Very High Very High
Stress 313 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we report analyses regarding expression of the melanocyte-stimulating hormone (MSH) receptor (melanocortin-1 receptor, MC1-R) and the melanogenic proteins, tyrosinase (E.C. 1.14.18.1), tyrosinase-related protein 1 (TRP-1), and the tyrosinase-related protein 2 (TRP-2, E.C. 5.3.2.3), by a panel of cell lines consisting of parental Cloudman S91 melanoma cells, macrophages from DBA/2J mice, artificially derived macrophage x melanoma hybrids of high and low metastatic potential, and a naturally occurring highly metastatic hybrid between a Cloudman S91 tumor cell and a DBA/2J tumor-infiltrating cell.
Spec (analyses) Gene_expression (expression) of tyrosinase-related in macrophage associated with melanocortin 1 receptor, cancer and skin cancer
1) Confidence 0.66 Published 1999 Journal Pigment Cell Res. Section Abstract Doc Link 10614575 Disease Relevance 0.61 Pain Relevance 0.17
Here we report analyses regarding expression of the melanocyte-stimulating hormone (MSH) receptor (melanocortin-1 receptor, MC1-R) and the melanogenic proteins, tyrosinase (E.C. 1.14.18.1), tyrosinase-related protein 1 (TRP-1), and the tyrosinase-related protein 2 (TRP-2, E.C. 5.3.2.3), by a panel of cell lines consisting of parental Cloudman S91 melanoma cells, macrophages from DBA/2J mice, artificially derived macrophage x melanoma hybrids of high and low metastatic potential, and a naturally occurring highly metastatic hybrid between a Cloudman S91 tumor cell and a DBA/2J tumor-infiltrating cell.
Spec (analyses) Gene_expression (expression) of tyrosinase-related in macrophage associated with melanocortin 1 receptor, cancer and skin cancer
2) Confidence 0.66 Published 1999 Journal Pigment Cell Res. Section Abstract Doc Link 10614575 Disease Relevance 0.61 Pain Relevance 0.17
Here we report analyses regarding expression of the melanocyte-stimulating hormone (MSH) receptor (melanocortin-1 receptor, MC1-R) and the melanogenic proteins, tyrosinase (E.C. 1.14.18.1), tyrosinase-related protein 1 (TRP-1), and the tyrosinase-related protein 2 (TRP-2, E.C. 5.3.2.3), by a panel of cell lines consisting of parental Cloudman S91 melanoma cells, macrophages from DBA/2J mice, artificially derived macrophage x melanoma hybrids of high and low metastatic potential, and a naturally occurring highly metastatic hybrid between a Cloudman S91 tumor cell and a DBA/2J tumor-infiltrating cell.
Spec (analyses) Gene_expression (expression) of TRP-1 in macrophage associated with melanocortin 1 receptor, cancer and skin cancer
3) Confidence 0.66 Published 1999 Journal Pigment Cell Res. Section Abstract Doc Link 10614575 Disease Relevance 0.61 Pain Relevance 0.17
In in vivo experiments, 4- and 6-NO(2)Trp were detected in the liver of mice administered APAP.
Gene_expression (detected) of Trp in liver associated with paracetamol
4) Confidence 0.65 Published 2007 Journal J Pharm Biomed Anal Section Abstract Doc Link 17287102 Disease Relevance 0 Pain Relevance 0.24
The syntheses of Trp(Nps)-Arg-OMe.HCl (15) [Trp(Nps) = 2-[(o-nitrophenyl)sulfenyl]tryptophan], its three stereoisomers, and their corresponding cyclic analogues are reported.
Gene_expression (syntheses) of Trp
5) Confidence 0.56 Published 1988 Journal J. Med. Chem. Section Abstract Doc Link 3339602 Disease Relevance 0 Pain Relevance 0.23
The syntheses of Trp(Nps)-Arg-OMe.HCl (15) [Trp(Nps) = 2-[(o-nitrophenyl)sulfenyl]tryptophan], its three stereoisomers, and their corresponding cyclic analogues are reported.
Gene_expression (syntheses) of Trp
6) Confidence 0.56 Published 1988 Journal J. Med. Chem. Section Abstract Doc Link 3339602 Disease Relevance 0 Pain Relevance 0.23
TRP produced evident antiinflammatory effects of potency comparable with those of phenylbutazone when studied by means of carrageenin-induced rat paw oedema and prostaglandin synthetase activity in vitro.
Gene_expression (produced) of TRP in paw associated with pressure and volume under development, inflammation and potency
7) Confidence 0.51 Published 1987 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 2972998 Disease Relevance 0.50 Pain Relevance 0.16
In in vitro experiments demonstrated that all isomers of NO(2)Trp were detectable from BSA treated with ONOO(-) and the amount generated decreased in the order of 6-, 4- and 2-NO(2)Trp.
Neg (NO) Gene_expression (detectable) of Trp
8) Confidence 0.50 Published 2007 Journal J Pharm Biomed Anal Section Abstract Doc Link 17287102 Disease Relevance 0 Pain Relevance 0.24
A pigmented subclone of this microcell hybrid, however, re-expressed the tyrosinase, TRP-1, TRP-2, and microphthalmia genes.
Gene_expression (expressed) of TRP-1 associated with microphthalmia
9) Confidence 0.48 Published 1996 Journal Somat. Cell Mol. Genet. Section Abstract Doc Link 8643993 Disease Relevance 0.34 Pain Relevance 0
Since the only fibroblast chromosome detected in the unpigmented microcell hybrid was mouse chromosome 1, these results also suggest that the extinguisher locus affecting the expression of the tyrosinase, TRP-1, TRP-2, and microphthalmia genes in hybrid cells is located on that mouse chromosome (or on a fragment of another chromosome present in the unpigmented monochromosomal microcell hybrid but undetected in our analyses).
Gene_expression (expression) of TRP-1 in fibroblast associated with microphthalmia
10) Confidence 0.48 Published 1996 Journal Somat. Cell Mol. Genet. Section Abstract Doc Link 8643993 Disease Relevance 0.33 Pain Relevance 0.07
Acetaldehyde failed to activate other temperature-sensitive TRP channels expressed in sensory neurons.
Gene_expression (expressed) of TRP in sensory neurons associated with trp channel
11) Confidence 0.43 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17970723 Disease Relevance 0.36 Pain Relevance 0.33
It promotes transcription of melanocyte-specific gene products including melanosomal enzymes tyrosinase, TYRP1 and DCT and the matrix protein SILV/PMEL (Levy et al., 2006).
Gene_expression (products) of TYRP1 in melanocyte
12) Confidence 0.42 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0.18 Pain Relevance 0.38
These data demonstrate that pTT treatment increases eumelanogenesis in HFs, associated with increased tyrosinase, TRP-1 and MC-1R expression.
Gene_expression (expression) of TRP-1
13) Confidence 0.40 Published 2007 Journal Exp. Dermatol. Section Abstract Doc Link 17620094 Disease Relevance 0 Pain Relevance 0.07
Melan-a cells treated with ASIP lose expression of TYRP1, DCT, and SILV/PMEL, all needed to generate normal eumelanosomes but not pheomelanosomes, while retaining low tyrosinase expression (Sakai et al., 1997) which would favor pheomelanogenesis (Ito, 2003).
Gene_expression (expression) of TYRP1
14) Confidence 0.38 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.08
Analysis of melanocyte-specific transcripts using reverse transcription, combined with the polymerase chain reaction (RT-PCR), demonstrated that tyrosinase, TRP-1, TRP-2, and microphthalmia transcripts were all absent in unpigmented whole-cell hybrids and in the monochromosomal unpigmented microcell hybrid.
Neg (absent) Gene_expression (absent) of TRP-1 in melanocyte associated with microphthalmia
15) Confidence 0.37 Published 1996 Journal Somat. Cell Mol. Genet. Section Abstract Doc Link 8643993 Disease Relevance 0.33 Pain Relevance 0
Marked increase in plasma Trp and altered plasma Trp metabolite levels in Tdo-/- adult mice
Gene_expression (levels) of Trp in plasma
16) Confidence 0.37 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.09 Pain Relevance 0
Measurement of the three Trp catabolites in plasma by HPLC showed much higher levels of 5-HIAA, the catabolic product of Trp via the serotonin (5-HT) pathway (Figure 1A(b)), in Tdo-/- than Tdo+/+ mice (Figure 2C), as well as increases in indoleacetic acid (IAA) and indolelactic acid (ILA) (Figure 2D and 2E), products of Trp via the transamination pathway (Figure 1A(c)).
Gene_expression (product) of Trp in plasma associated with serotonin
17) Confidence 0.37 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.13 Pain Relevance 0.05
Measurement of the three Trp catabolites in plasma by HPLC showed much higher levels of 5-HIAA, the catabolic product of Trp via the serotonin (5-HT) pathway (Figure 1A(b)), in Tdo-/- than Tdo+/+ mice (Figure 2C), as well as increases in indoleacetic acid (IAA) and indolelactic acid (ILA) (Figure 2D and 2E), products of Trp via the transamination pathway (Figure 1A(c)).
Gene_expression (products) of Trp in plasma associated with serotonin
18) Confidence 0.37 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.15 Pain Relevance 0.05
These findings clearly demonstrated that TDO is indeed largely responsible for the systemic level of Trp, and that TDO contributes to Trp catabolites (5-HIAA, ILA, and IAA) levels in plasma, even in the presence of IDO.
Gene_expression (level) of Trp in plasma
19) Confidence 0.37 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.09 Pain Relevance 0.04
Measurement of the three Trp catabolites in plasma by HPLC showed much higher levels of 5-HIAA, the catabolic product of Trp via the serotonin (5-HT) pathway (Figure 1A(b)), in Tdo-/- than Tdo+/+ mice (Figure 2C), as well as increases in indoleacetic acid (IAA) and indolelactic acid (ILA) (Figure 2D and 2E), products of Trp via the transamination pathway (Figure 1A(c)).
Gene_expression (products) of Trp in plasma associated with serotonin
20) Confidence 0.37 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.09 Pain Relevance 0.05

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