INT326509

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.07
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ACE, VWF) endosome (ACE) endoplasmic reticulum (VWF)
extracellular space (ACE) peptidase activity (ACE) proteinaceous extracellular matrix (VWF)
ACE (Homo sapiens)
VWF (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 130 100.00 Very High Very High Very High
headache 38 100.00 Very High Very High Very High
excitatory amino acid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 162 100.00 Very High Very High Very High
Disease 2 75.32 Quite High
Migraine With Aura 42 61.84 Quite High
Cardiovascular Disease 2 58.92 Quite High
Migraine Without Aura 10 53.12 Quite High
Hypertension 4 19.08 Low Low
Stroke 4 14.08 Low Low
Epilepsy 8 10.48 Low Low
Increased Venous Pressure Under Development 4 5.28 Low Low
Stress 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent study by Tietjen et al. [22], that investigated if angiotensin converting enzyme (ACE) and MTHFR gene variants are associated with von Willebrand factor (vWF) activity, an endothelial dysfunction marker, and with a distinct headache phenotype in premenopausal women with migraine, observed elevated vWF activity to be associated with the ACE DD genotype, which was highest when combined with the MTHFR TT genotype [22].
ACE DD Binding (associated) of vWF associated with migraine and headache
1) Confidence 0.05 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2919563 Disease Relevance 1.11 Pain Relevance 0.81
A recent study by Tietjen et al. [22], that investigated if angiotensin converting enzyme (ACE) and MTHFR gene variants are associated with von Willebrand factor (vWF) activity, an endothelial dysfunction marker, and with a distinct headache phenotype in premenopausal women with migraine, observed elevated vWF activity to be associated with the ACE DD genotype, which was highest when combined with the MTHFR TT genotype [22].
ACE DD Binding (associated) of vWF associated with migraine and headache
2) Confidence 0.05 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2919563 Disease Relevance 0.96 Pain Relevance 0.78

General Comments

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