INT326554

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.02
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Zic2) nucleus (Zic2) DNA binding (Zic2)
Anatomy Link Frequency
midline 1
Zic2 (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 20 92.28 High High
unmyelinated 14 91.36 High High
fluoxetine 20 85.84 High High
Serotonin 66 69.28 Quite High
hypoalgesia 8 68.04 Quite High
Sciatic nerve 6 12.12 Low Low
Raphe 8 5.00 Very Low Very Low Very Low
monoamine 4 5.00 Very Low Very Low Very Low
diabetic neuropathy 4 5.00 Very Low Very Low Very Low
Neuropathic pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 10 99.12 Very High Very High Very High
Diabetes Mellitus 80 98.88 Very High Very High Very High
Handedness 24 97.96 Very High Very High Very High
Demyelinating Disease 20 92.28 High High
Death 28 90.72 High High
Wound Healing 2 78.92 Quite High
Insulin Resistance 4 77.12 Quite High
Targeted Disruption 4 70.80 Quite High
Hypoalagesia 8 68.04 Quite High
Muscular Atrophy 2 64.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Zic2 modulates refinement at the SC independently of controlling laterality at the midline
Regulation (modulates) of Zic2 in midline associated with handedness
1) Confidence 0.39 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.18 Pain Relevance 0.23
To determine if Sert is a direct transcriptional target of Zic2, we investigated whether this transcription factor activates Sert regulatory sequences.
Regulation (target) of Zic2
2) Confidence 0.27 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
Hsp70 is a critical mechanistic component necessary for the efficacy of KU-32 in improving a major neurodegenerative complication of diabetes.
Regulation (efficacy) of KU-32 associated with diabetes mellitus and neurodegenerative disease
3) Confidence 0.01 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2919983 Disease Relevance 1.06 Pain Relevance 0.09
To define the relative contribution of Hsp70 to the efficacy of KU-32, we examined the effect of diabetes and KU-32 treatment on the development of DPN in the Hsp70 KO mice.
Regulation (efficacy) of KU-32 associated with diabetes mellitus
4) Confidence 0.01 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2919983 Disease Relevance 0.78 Pain Relevance 0.07

General Comments

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