INT326561

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.27
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Zic2) nucleus (Zic2) DNA binding (Zic2)
Anatomy Link Frequency
retina 1
peripheral nerve 1
Zic2 (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 3 96.44 Very High Very High Very High
unmyelinated 7 82.32 Quite High
Demyelination 10 54.44 Quite High
hypoalgesia 4 50.00 Quite Low
Serotonin 99 25.40 Quite Low
fluoxetine 30 5.00 Very Low Very Low Very Low
Raphe 12 5.00 Very Low Very Low Very Low
monoamine 6 5.00 Very Low Very Low Very Low
primary somatosensory cortex 3 5.00 Very Low Very Low Very Low
Thalamus 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 14 83.64 Quite High
Body Weight 1 72.80 Quite High
Toxicity 1 59.28 Quite High
Demyelinating Disease 10 54.44 Quite High
Diabetes Mellitus 40 50.00 Quite Low
Shock 7 50.00 Quite Low
Hypoalagesia 4 50.00 Quite Low
Stress 7 26.24 Quite Low
Adhesions 3 17.08 Low Low
Handedness 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further test whether Zic2 is required for Sert expression in the VT region of the retina, we examined Sert mRNA levels in Zic2 hypomorphic mutant mice (Zic2kd/kd).
Positive_regulation (required) of Zic2 in retina
1) Confidence 0.50 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
Zic2 is necessary and sufficient to induce the expression of Sert
Positive_regulation (sufficient) of Zic2
2) Confidence 0.47 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
Zic2 is necessary and sufficient to induce the expression of Sert
Positive_regulation (necessary) of Zic2
3) Confidence 0.47 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
Although the accumulation of KU-32 in peripheral nerve has not been assessed, the level of Hsp70 was modestly increased in sciatic nerve at 1 week after drug administration (Figure 4B).
Positive_regulation (accumulation) of KU-32 in peripheral nerve associated with sciatic nerve
4) Confidence 0.02 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2919983 Disease Relevance 0.27 Pain Relevance 0.15

General Comments

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