INT326573

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.95
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Zic2, Hsf1) DNA binding (Zic2, Hsf1) cell differentiation (Zic2)
protein complex (Hsf1) response to stress (Hsf1) cytoplasm (Hsf1)
Anatomy Link Frequency
HSF 2
Zic2 (Mus musculus)
Hsf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 10 73.16 Quite High
unmyelinated 7 72.24 Quite High
hypoalgesia 4 50.00 Quite Low
Sciatic nerve 3 5.00 Very Low Very Low Very Low
diabetic neuropathy 2 5.00 Very Low Very Low Very Low
Painful diabetic neuropathy 1 5.00 Very Low Very Low Very Low
dorsal root ganglion 1 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 2 91.36 High High
Diabetes Mellitus 40 84.12 Quite High
Neurodegenerative Disease 5 83.12 Quite High
Apoptosis 3 75.04 Quite High
Demyelinating Disease 10 73.16 Quite High
Death 14 71.60 Quite High
Wound Healing 1 59.80 Quite High
Targeted Disruption 2 51.68 Quite High
Shock 7 50.00 Quite Low
Hypoalagesia 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reliance on Hsp70 expression for neuroprotection suggests that if KU-32 promotes a broader HSR via the release of HSF-1, this is not sufficient for drug efficacy.
KU-32 Positive_regulation (promotes) of Localization (release) of HSF-1 in HSF
1) Confidence 0.01 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2919983 Disease Relevance 0.95 Pain Relevance 0.07

General Comments

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