INT326586

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.91
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (SLC18A2, DDC) small molecule metabolic process (DDC) lyase activity (DDC)
aging (SLC18A2) enzyme binding (SLC18A2) transmembrane transport (SLC18A2)
Anatomy Link Frequency
striatum 1
SLC18A2 (Homo sapiens)
DDC (Homo sapiens)
Pain Link Frequency Relevance Heat
monoamine 6 99.58 Very High Very High Very High
Dopamine 78 98.70 Very High Very High Very High
positron emission tomography 46 97.22 Very High Very High Very High
Substantia nigra 6 89.56 High High
dopamine receptor 2 89.12 High High
imagery 23 75.92 Quite High
Neurotransmitter 2 57.60 Quite High
midbrain 5 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 66 97.78 Very High Very High Very High
Nerve Degeneration 7 75.16 Quite High
Parkinsonian Disorders 39 73.08 Quite High
Movement Disorders 1 55.12 Quite High
Parkinson's Disease 3 23.12 Low Low
Hypokinesia 5 14.44 Low Low
Tremor 12 9.44 Low Low
Congenital Anomalies 15 5.00 Very Low Very Low Very Low
Liver Disease 12 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Single photon emission computed tomography (SPECT) and positron emission tomography (PET) studies have shown that PD patients exhibit decreased levels of dopamine transporters (DATs) and vesicular monoamine transporter type 2 (VMAT2) and reduced activity of dopa decarboxylase as measured by the conversion of l-dopa to dopamine in the striatum using [18F]-fluoro-dopa PET (Felicio et al. 2009).
VMAT2 Negative_regulation (reduced) of dopa decarboxylase in striatum associated with dopamine, positron emission tomography, disease and monoamine
1) Confidence 0.28 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.91 Pain Relevance 0.66

General Comments

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