INT326587

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.83
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (DDC) lyase activity (DDC) cytoplasm (DDC)
cytosol (DDC) plasma membrane (GYPA) molecular_function (GYPA)
Anatomy Link Frequency
brain 1
GYPA (Homo sapiens)
DDC (Homo sapiens)
Pain Link Frequency Relevance Heat
positron emission tomography 46 98.84 Very High Very High Very High
Dopamine 78 97.90 Very High Very High Very High
imagery 23 17.12 Low Low
Substantia nigra 6 5.00 Very Low Very Low Very Low
monoamine 6 5.00 Very Low Very Low Very Low
midbrain 5 5.00 Very Low Very Low Very Low
dopamine receptor 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Liver Disease 12 99.20 Very High Very High Very High
Parkinsonian Disorders 39 92.68 High High
Nerve Degeneration 7 90.08 High High
Disease 66 86.24 High High
Congenital Anomalies 15 64.60 Quite High
Tremor 12 5.00 Very Low Very Low Very Low
Hypokinesia 5 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 5 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Parkinson's Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For the most part, available evidence from SPECT and PET studies of dopamine neuron terminal markers in ephedron addicts and in liver disease patients have confirmed the lack of an effect of elevated brain Mn on dopa decarboxylase activity using [18F]-l-dopa PET and on DAT levels in the striatum (Colosimo and Guidi 2009; de Bie et al. 2007; Kim et al. 2007; Selikhova et al. 2008; see Table 2).
Mn Regulation (effect) of dopa decarboxylase in brain associated with liver disease, dopamine and positron emission tomography
1) Confidence 0.08 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.83 Pain Relevance 0.33

General Comments

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