INT326592

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.15
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
projection neurons 2
basal ganglia 2
D1R (Vaccinia virus)
Pain Term Frequency Confidence Heat
Cannabinoid receptor 1 100.00 Very High Very High Very High
projection neuron 9 98.04 Very High Very High Very High
Dopamine 141 91.16 High High
Glutamate 6 90.92 High High
Ventral tegmentum 3 75.48 Quite High
Enkephalin 15 73.76 Quite High
Substantia nigra 12 73.44 Quite High
positron emission tomography 46 72.56 Quite High
substance P 15 67.12 Quite High
imagery 23 57.88 Quite High
Disease Term Frequency Confidence Heat
Body Weight 4 74.84 Quite High
Disease 66 50.00 Quite Low
Hypokinesia 5 5.00 Very Low Very Low Very Low
Focal Dystonia 1 5.00 Very Low Very Low Very Low
Poisoning 2 5.00 Very Low Very Low Very Low
Parkinson's Disease 3 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Liver Disease 12 5.00 Very Low Very Low Very Low
Tremor 12 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further studies are clearly warranted to determine how the specificity of D1R and D2R expression, as well as that of other genes, is controlled in the two populations of striatal MSNs during development.
Spec (determine) Regulation (specificity) of Gene_expression (expression) of D1R
1) Confidence 0.38 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.12
The hypothesis of a segregated expression of D1R and D2R in the distinct populations of striatal projection neurons was initially suggested by indirect evidence (Beckstead, 1988) and subsequently shown by retrograde tracing (Gerfen et al., 1990).
Regulation (segregated) of Gene_expression (expression) of D1R in projection neurons associated with projection neuron
2) Confidence 0.28 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.50
It was suggested that the developmental regulation of D1R and D2R mRNAs would result from intrinsic genetic programs, while the dopaminergic innervation would control the D1R and D2R protein synthesis (Jung and Bennett, 1996).
Regulation (control) of Gene_expression (synthesis) of D1R
3) Confidence 0.28 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.12
Further, Mn exposure had no effect on D1R or cannabinoid receptor 1 levels in the basal ganglia.
Neg (no) Regulation (effect) of Gene_expression (levels) of D1R in basal ganglia associated with cannabinoid receptor
4) Confidence 0.08 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.15 Pain Relevance 0.24

General Comments

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