INT326599

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.88
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GYPA) molecular_function (GYPA) cellular_component (GYPA)
biological_process (GYPA)
Anatomy Link Frequency
brain 2
GYPA (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 23 56.96 Quite High
positron emission tomography 46 48.24 Quite Low
Dopamine 78 42.20 Quite Low
Substantia nigra 6 30.88 Quite Low
midbrain 5 23.84 Low Low
monoamine 6 5.00 Very Low Very Low Very Low
dopamine receptor 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 15 98.64 Very High Very High Very High
Disease 66 95.28 Very High Very High Very High
Parkinsonian Disorders 39 87.44 High High
Parkinson's Disease 3 81.44 Quite High
Alcoholic Liver Cirrhosis 1 79.92 Quite High
Nerve Degeneration 7 43.00 Quite Low
Liver Disease 12 39.28 Quite Low
Tremor 12 5.00 Very Low Very Low Very Low
Hypokinesia 5 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, the evidence from neuroimaging studies have indicated that in different human conditions where Mn concentrations markedly increase in the brain to produce movement abnormalities, there is a lack of degeneration of the nigrostriatal dopaminergic terminals.


Positive_regulation (increase) of Mn Binding (concentrations) of in brain associated with congenital anomalies
1) Confidence 0.14 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.88 Pain Relevance 0.03

General Comments

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