INT326599

Context Info Confidence 0.14 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.88 Pain Relevance 0.03

plasma membrane (GYPA) molecular_function (GYPA) cellular_component (GYPA) biological_process (GYPA)

Anatomy Link Frequency brain 2 GYPA (Homo sapiens)

Pain Link Frequency Relevance Heat imagery 23 56.96 positron emission tomography 46 48.24 Dopamine 78 42.20 Substantia nigra 6 30.88 midbrain 5 23.84 monoamine 6 5.00 dopamine receptor 2 5.00 Neurotransmitter 2 5.00 antagonist 2 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Congenital Anomalies 15 98.64 Disease 66 95.28 Parkinsonian Disorders 39 87.44 Parkinson's Disease 3 81.44 Alcoholic Liver Cirrhosis 1 79.92 Nerve Degeneration 7 43.00 Liver Disease 12 39.28 Tremor 12 5.00 Hypokinesia 5 5.00 Drug Induced Neurotoxicity 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In summary, the evidence from neuroimaging studies have indicated that in different human conditions where Mn concentrations markedly increase in the brain to produce movement abnormalities, there is a lack of degeneration of the nigrostriatal dopaminergic terminals.

Positive_regulation (increase) of Mn Binding (concentrations) of in brain associated with congenital anomalies

1) Confidence 0.14 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.88 Pain Relevance 0.03

General Comments

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