INT326601

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.31
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (SLC18A2) plasma membrane (SLC18A2) enzyme binding (SLC18A2)
transmembrane transport (SLC18A2) cytoplasm (SLC18A2)
Anatomy Link Frequency
pituitary 1
striatum 1
SLC18A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 90 100.00 Very High Very High Very High
monoamine 14 100.00 Very High Very High Very High
positron emission tomography 46 98.88 Very High Very High Very High
cocaine 39 96.84 Very High Very High Very High
Substantia nigra 6 92.88 High High
dopamine receptor 2 85.60 High High
imagery 51 79.24 Quite High
Catecholamine 6 63.28 Quite High
Neurotransmitter 8 54.08 Quite High
alcohol 103 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 66 99.44 Very High Very High Very High
Fetal Hypoxia 1 92.36 High High
Increased Venous Pressure Under Development 2 87.48 High High
Nerve Degeneration 7 78.48 Quite High
Parkinsonian Disorders 39 76.40 Quite High
Drug Induced Neurotoxicity 7 74.52 Quite High
Apoptosis 3 71.16 Quite High
Movement Disorders 1 58.44 Quite High
Congenital Anomalies 62 50.00 Quite Low
Parkinson's Disease 3 19.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like cocaine, methamphetamine could also alter the developmental trajectory of the fetus by acting on the hypothalamus-pituitary-adrenal axis, disrupting fetal placental monoamine transporter expression, and altering gene expression through epigenetic mechanisms, such as chromatin remodeling and DNA methylation (Salisbury et al. 2009).
Gene_expression (expression) of monoamine transporter in pituitary associated with monoamine and cocaine
1) Confidence 0.42 Published 2010 Journal Neuropsychol Rev Section Body Doc Link PMC2988996 Disease Relevance 0.38 Pain Relevance 0.25
Single photon emission computed tomography (SPECT) and positron emission tomography (PET) studies have shown that PD patients exhibit decreased levels of dopamine transporters (DATs) and vesicular monoamine transporter type 2 (VMAT2) and reduced activity of dopa decarboxylase as measured by the conversion of l-dopa to dopamine in the striatum using [18F]-fluoro-dopa PET (Felicio et al. 2009).
Gene_expression (levels) of VMAT2 in striatum associated with dopamine, positron emission tomography, disease and monoamine
2) Confidence 0.35 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.92 Pain Relevance 0.67

General Comments

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