INT326605

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.45
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1A, KCNH2) nuclear envelope (KCNH2) transmembrane transport (KCNH2)
cytoplasm (KCNH2) signal transducer activity (HTR1A)
HTR1A (Homo sapiens)
KCNH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 100.00 Very High Very High Very High
Pain 3 57.44 Quite High
nud 2 19.84 Low Low
Inflammation 2 5.52 Low Low
Biofeedback 12 5.00 Very Low Very Low Very Low
Opioid 6 5.00 Very Low Very Low Very Low
spastic colon 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Piles 2 5.00 Very Low Very Low Very Low
opioid receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Constipation 80 90.80 High High
Pain 3 57.44 Quite High
Hepatotoxicity 1 51.92 Quite High
Hypersensitivity 1 51.16 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

6 49.40 Quite Low
Dyspepsia 2 19.84 Low Low
Diarrhoea 5 15.84 Low Low
Crystal Associated Disease 1 6.88 Low Low
INFLAMMATION 1 5.52 Low Low
Aging 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prucalopride, a dihydrobenzofurancarboxamide derivative, is a selective high-affinity 5HT4 receptor agonist.42 Unlike other drugs in its class, such as tegaserod, mosapride and renzapride, prucalopride has a lower affinity for the human Ether-a-go-go Related Gene protein (hERG).42 It is believed that the effects on the hERG channel may have led to the unfavorable cardiovascular profile seen with tegaserod.
5HT4 receptor Binding (affinity) of hERG associated with agonist
1) Confidence 0.00 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2920196 Disease Relevance 0.45 Pain Relevance 0.14

General Comments

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