INT326665

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.24
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Cpe) cytoplasm (Oprd1) signal transducer activity (Oprd1)
extracellular space (Cpe) peptidase activity (Cpe) signal transduction (Oprd1)
Anatomy Link Frequency
neurons 1
Cpe (Mus musculus)
Oprd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 9 100.00 Very High Very High Very High
opioid receptor 4 100.00 Very High Very High Very High
Pain 21 98.80 Very High Very High Very High
Glutamate 7 98.32 Very High Very High Very High
Inflammation 5 97.20 Very High Very High Very High
Spinal cord 25 95.48 Very High Very High Very High
GABAergic 5 81.80 Quite High
gABA 2 75.76 Quite High
Dorsal horn neuron 6 64.56 Quite High
Dorsal horn 12 61.08 Quite High
Disease Link Frequency Relevance Heat
Pain 28 98.80 Very High Very High Very High
INFLAMMATION 5 97.20 Very High Very High Very High
Aids-related Complex 131 94.56 High High
Nociception 41 94.32 High High
Targeted Disruption 34 73.20 Quite High
Generalized Anxiety Disorder 1 67.20 Quite High
Inflammatory Pain 4 6.32 Low Low
Depression 7 5.00 Very Low Very Low Very Low
Neuropathic Pain 7 5.00 Very Low Very Low Very Low
Nervous System Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the activation of the delta opioid receptor (DOR), through which enkephalin exerts its effect, decreases pain behavior during chronic peripheral inflammation [41], we tend to conclude that the overall effect of Arc/Arg3.1 expressing enkephalinergic neurons is anti-nociceptive.
enkephalin Positive_regulation (activation) of delta opioid receptor in neurons associated with nociception, pain, inflammation, aids-related complex, enkephalin and opioid receptor
1) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.24 Pain Relevance 1.15

General Comments

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