INT326714

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Context Info
Confidence 0.34
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.68
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sox10) nucleus (Sox10) DNA binding (Sox10)
transcription factor binding (Sox10) cytoplasm (Sox10)
Sox10 (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 2 91.08 High High
Cancer 328 80.40 Quite High
Carcinoma 28 75.00 Quite High
Targeted Disruption 24 59.20 Quite High
Adenocarcinoma 6 5.00 Very Low Very Low Very Low
Breast Cancer 6 5.00 Very Low Very Low Very Low
Metastasis 4 5.00 Very Low Very Low Very Low
Solid Tumor 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, siRNA mediated depletion of Sox10 resulted in a significant up-regulation of Twist2, but in no or only a slight regulation of epithelial-specific TFs (Figure 13D), indicating that Sox10 probably has a function in dampening EMT progression in G-2 cells via repression of Twist2.
Negative_regulation (depletion) of Sox10 associated with repression
1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.27 Pain Relevance 0
The balance between differentiation states is regulated in part by the transcription factor Sox10, as depletion of Sox10 led to up-regulation of Twist2 and increased the proportion of Thy1-expressing cells representing cells in a self-renewable, reversible, quasi-mesenchymal differentiation state.


Negative_regulation (depletion) of Sox10
2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920333 Disease Relevance 0.41 Pain Relevance 0

General Comments

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