INT326726

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.84
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Itk) cell differentiation (Twist1) nucleus (Twist1)
DNA binding (Twist1) kinase activity (Itk) transcription factor binding (Twist1)
Twist1 (Mus musculus)
Itk (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 164 99.70 Very High Very High Very High
Hypoxia 1 99.14 Very High Very High Very High
Targeted Disruption 12 70.04 Quite High
Carcinoma 14 50.00 Quite Low
Adenocarcinoma 3 5.00 Very Low Very Low Very Low
Breast Cancer 3 5.00 Very Low Very Low Very Low
Metastasis 2 5.00 Very Low Very Low Very Low
Solid Tumor 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon moderate hypoxic conditions epithelial tumor cells undergo EMT [69], which is transcriptionally regulated by Hif-1alpha and its downstream target Twist1 [70]; conversely, hyperbaric oxygen treatment triggers a reversed process, MET [71].
Twist1 Regulation (regulated) of EMT associated with cancer and hypoxia
1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.84 Pain Relevance 0

General Comments

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