INT326737

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.41
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL8, ARG1) small molecule metabolic process (ARG1) intracellular (IL8)
cytoplasm (ARG1) cytosol (ARG1) signal transduction (IL8)
IL8 (Homo sapiens)
ARG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 21 90.08 High High
palliative 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 111 98.84 Very High Very High Very High
Hyperplasia 12 98.44 Very High Very High Very High
Reprotox - General 1 162 90.08 High High
Malignant Neoplastic Disease 30 72.96 Quite High
Colon Cancer 3 61.24 Quite High
Breast Cancer 3 60.48 Quite High
Toxicity 3 32.92 Quite Low
Apoptosis 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Recurrence 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, we showed that IL-8 was also regulated by R1881 and could stimulate the expression of ARG1 and ARG2 independently of androgen.
IL-8 Neg (independently) Positive_regulation (stimulate) of Gene_expression (expression) of ARG1
1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 1.22 Pain Relevance 0
Finally, we observed that IL-8 was upregulated following androgen stimulation and could induce the expression of ARG1 and ARG2.
IL-8 Positive_regulation (induce) of Gene_expression (expression) of ARG1
2) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.74 Pain Relevance 0.03
IL-8 induction of ARG1 and ARG2 expression
IL-8 Positive_regulation (induction) of Gene_expression (expression) of ARG1
3) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.45 Pain Relevance 0.16

General Comments

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