INT32675

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Context Info
Confidence 0.39
First Reported 1988
Last Reported 2007
Negated 2
Speculated 2
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 0.45
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Amph) cytoplasm (Amph)
Anatomy Link Frequency
striatum 2
cerebral cortex 1
Amph (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 722 100.00 Very High Very High Very High
Thalamus 1 99.62 Very High Very High Very High
cerebral cortex 1 99.28 Very High Very High Very High
Morphine 1 97.82 Very High Very High Very High
anesthesia 12 97.44 Very High Very High Very High
Ventral tegmentum 21 97.16 Very High Very High Very High
Opioid 9 97.12 Very High Very High Very High
isoflurane 15 92.88 High High
Versed 1 89.00 High High
imagery 35 85.44 High High
Disease Link Frequency Relevance Heat
Body Weight 1 89.96 High High
Congenital Anomalies 7 87.88 High High
Hyperglycemia 7 78.16 Quite High
Diabetes Mellitus 42 69.88 Quite High
Apoptosis 8 58.52 Quite High
Amphetamine Dependence 7 25.00 Low Low
Drug Dependence 14 20.40 Low Low
Appetite Loss 7 19.72 Low Low
Opiate Addiction 7 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Animals treated simultaneously with 1 mg/kg IP morphine or 5 micrograms/kg IP beta-endorphin and repeated AMPH injections for one day, showed a reduced stereotyped response to AMPH or APO.
Regulation (response) of AMPH associated with morphine
1) Confidence 0.39 Published 1988 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2976168 Disease Relevance 0 Pain Relevance 0.46
This is because the analysis of the rising phase of the HSCA traces revealed that the rate of AMPH-induced DA efflux in STZ-treated rats was severely attenuated compared with that of saline-treated control rats (Figure 2B).
Regulation (efflux) of AMPH-induced associated with dopamine
2) Confidence 0.30 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.60
These data further support our hypothesis that STZ treatment, by decreasing PI3K signaling in striatum, downregulates AMPH-induced DA efflux measured by HSCA (Figures 2, 3 and 6) and fMRI (Figure 5).
Regulation (downregulates) of AMPH-induced in striatum associated with dopamine
3) Confidence 0.30 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.17 Pain Relevance 0.27
Likewise, prelimbic and cingulate cortices, also innervated by the VTA and where the norepinephrine transporter is the predominant carrier supporting DA inactivation [61], failed to show significant differential AMPH-induced BOLD responses after STZ (unpublished data).


Neg (failed) Regulation (responses) of AMPH-induced associated with ventral tegmentum and dopamine
4) Confidence 0.30 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.23
To verify whether inhibition of PI3K signaling induced by STZ treatment correlates with changes in AMPH-induced DA efflux, we used HSCA to measure the release and clearance kinetics of striatal DA in vivo [14,40].
Spec (whether) Regulation (changes) of AMPH-induced associated with dopamine
5) Confidence 0.30 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.07 Pain Relevance 0.19
In contrast, there was no significant AMPH-induced BOLD signal change from baseline in STZ-pretreated, insulin-depleted rats (Figure 5B).
Neg (no) Regulation (change) of AMPH-induced
6) Confidence 0.18 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.15
In vitro studies suggest that hypoinsulinemia may regulate the actions of AMPH by inhibiting the insulin downstream effectors phosphotidylinositol 3-kinase (PI3K) and protein kinase B (PKB, or Akt), which we have previously shown are able to fine-tune DAT cell-surface expression.
Spec (may) Regulation (regulate) of AMPH
7) Confidence 0.18 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.21
Here we show that pharmacological manipulation of the PI3K signaling pathway caused by hypoinsulinemic conditions or selective pharmacological inhibition/activation of PI3K dramatically regulates the ability of AMPH to evoke DAT-mediated DA release in the striatum, as determined by HSCA.
Regulation (regulates) of AMPH in striatum associated with dopamine
8) Confidence 0.18 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.07 Pain Relevance 0.25
We found that this general anesthesia causes permanent neuronal deletion in the most vulnerable brain regions-the cerebral cortex and the thalamus-while transiently modulating protein levels of synaptophysin, synaptobrevin, amphiphysin, SNAP-25, and CaM kinase II.
Regulation (modulating) of amphiphysin in cerebral cortex associated with anesthesia, thalamus and cerebral cortex
9) Confidence 0.17 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18077565 Disease Relevance 0.15 Pain Relevance 0.53

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