INT32676

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Context Info
Confidence 0.50
First Reported 1988
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 0.38
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Amph) cytoplasm (Amph)
Anatomy Link Frequency
substantia nigra 1
cerebral cortex 1
striatum 1
Amph (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 516 100.00 Very High Very High Very High
cerebral cortex 1 100.00 Very High Very High Very High
Thalamus 1 100.00 Very High Very High Very High
anesthesia 10 99.98 Very High Very High Very High
Substantia nigra 5 99.12 Very High Very High Very High
isoflurane 11 97.96 Very High Very High Very High
Morphine 1 94.16 High High
Versed 1 94.08 High High
narcan 4 93.00 High High
Eae 10 92.12 High High
Disease Link Frequency Relevance Heat
Body Weight 1 95.04 Very High Very High Very High
Diabetes Mellitus 30 89.72 High High
Drug Dependence 10 73.92 Quite High
Apoptosis 6 63.60 Quite High
Congenital Anomalies 5 57.68 Quite High
Hyperglycemia 5 47.96 Quite Low
Amphetamine Dependence 5 25.00 Low Low
Appetite Loss 5 20.48 Low Low
Opiate Addiction 5 11.24 Low Low
Attention Deficit Hyperactivity Disorder 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When repeated injections of AMPH were given only one day, the diminished stereotypy response to AMPH or APO was not observed.
Positive_regulation (response) of AMPH
1) Confidence 0.50 Published 1988 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2976168 Disease Relevance 0 Pain Relevance 0.46
Hybridization performed 3 h after AMPH challenge in AMPH-pretreated rats failed to demonstrate augmentation of AMPH-stimulated zif/268, PPD, or PPE mRNA expression in the striatum as compared to saline-pretreated rats.
Positive_regulation (augmentation) of AMPH in striatum
2) Confidence 0.38 Published 1995 Journal Brain Res. Section Abstract Doc Link 7606440 Disease Relevance 0 Pain Relevance 0.04
M/125 nl) almost fully restored to control levels the rate and the amount of AMPH-evoked DA release (Figure 6A and 6B), as well as the rate of DAT-mediated clearance (Figure 6C).
Positive_regulation (restored) of AMPH-evoked DA release associated with dopamine
3) Confidence 0.38 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.07 Pain Relevance 0.35
To quantify the effects of hypoinsulinemia on the striatal BOLD signal we performed region-of-interest (ROI) analysis of dorsolateral portions of this structure, which is predominantly innervated by the substantia nigra compacta and where t-maps indicated strong AMPH-evoked BOLD activation that was sensitive to insulin depletion.
Positive_regulation (activation) of AMPH-evoked in substantia nigra associated with substantia nigra
4) Confidence 0.33 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.11
These AMPH-induced increases are achieved by DA transporter (DAT)-mediated transmitter efflux.
Positive_regulation (increases) of AMPH-induced associated with dopamine
5) Confidence 0.33 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.20
Figure 6 shows that local application of insulin in STZ-treated rats almost completely restores AMPH-stimulated DA efflux.
Positive_regulation (restores) of AMPH associated with dopamine
6) Confidence 0.33 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.06 Pain Relevance 0.33
Likewise, the reinforcing potential of AMPH, as determined by the daily maintenance of intravenous AMPH self-administration, is significantly blunted in the STZ model of hypoinsulinemia [12].
Spec (determined) Positive_regulation (maintenance) of AMPH
7) Confidence 0.31 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.09 Pain Relevance 0.27
We found that this general anesthesia causes permanent neuronal deletion in the most vulnerable brain regions-the cerebral cortex and the thalamus-while transiently modulating protein levels of synaptophysin, synaptobrevin, amphiphysin, SNAP-25, and CaM kinase II.
Positive_regulation (causes) of amphiphysin in cerebral cortex associated with anesthesia, thalamus and cerebral cortex
8) Confidence 0.29 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18077565 Disease Relevance 0.16 Pain Relevance 0.60

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