INT326763

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Context Info
Confidence 0.57
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.49
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARG1) extracellular space (ARG1) small molecule metabolic process (ARG1)
cellular nitrogen compound metabolic process (ARG1) cytoplasm (ARG1)
ARG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 5 70.72 Quite High
cytokine 35 66.56 Quite High
palliative 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 270 87.08 High High
Hyperplasia 20 78.88 Quite High
Cancer 185 72.56 Quite High
Malignant Neoplastic Disease 50 68.92 Quite High
Toxicity 5 51.84 Quite High
Apoptosis 5 5.00 Very Low Very Low Very Low
Breast Cancer 5 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Colon Cancer 5 5.00 Very Low Very Low Very Low
Recurrence 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of either ARG1 or ARG2 resulted in diminished arginase enzymatic activity (Figure 4B).
Negative_regulation (Inhibition) of ARG1
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.48 Pain Relevance 0
This reduced IL-8 production was associated with a reduction of ARG1 and ARG2 24 hrs following R1881 stimulation (Figure 5E).
Negative_regulation (reduction) of ARG1
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.24 Pain Relevance 0.12
The absence of either ARG1 or ARG2 led to higher concentrations of l-arginine in the conditioned media suggesting a lower metabolism of l-arginine by LNCaP cells (Figure 4C).
Negative_regulation (absence) of ARG1
3) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.37 Pain Relevance 0
The inhibition of either ARG1 or ARG2 translated into increased PBMC proliferation as quantified by BrdU incorporation (Figure 4E, left panel).
Negative_regulation (inhibition) of ARG1
4) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.14 Pain Relevance 0
Both the ARG1 and ARG2 induction following R1881 stimulation were inhibited by the siRNA treatment, which translated in the absence of an upregulation in arginase activity (Figure 2F).
Negative_regulation (inhibited) of ARG1
5) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.25 Pain Relevance 0.04

General Comments

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