INT326766

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Context Info
Confidence 0.67
First Reported 2010
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 8.32
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARG1) extracellular space (ARG1) small molecule metabolic process (ARG1)
cellular nitrogen compound metabolic process (ARG1) cytoplasm (ARG1)
Anatomy Link Frequency
stroma 2
macrophage 2
skin 2
ARG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 22 99.00 Very High Very High Very High
Inflammation 122 98.80 Very High Very High Very High
chemokine 21 88.08 High High
cytokine 91 79.76 Quite High
Inflammatory response 3 74.48 Quite High
agonist 10 51.12 Quite High
palliative 10 29.76 Quite Low
aspirin 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 540 99.36 Very High Very High Very High
Toxicity 11 99.12 Very High Very High Very High
Psoriasis 40 99.00 Very High Very High Very High
Polyps 58 98.96 Very High Very High Very High
INFLAMMATION 124 98.80 Very High Very High Very High
Adenoma 72 98.52 Very High Very High Very High
Malignant Neoplastic Disease 138 97.68 Very High Very High Very High
Cancer 404 96.84 Very High Very High Very High
Cleidocranial Dysplasia 36 93.40 High High
Carcinoma 8 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The AR was implicated in this regulation as both bicalutamide and siAR transfection prevented ARG1 and ARG2 overexpression following R1881 stimulation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ARG1
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.75 Pain Relevance 0
In this report, we observed that androgens induced the expression of both ARG1 and ARG2 in HS PCa cell lines.
Positive_regulation (induced) of Gene_expression (expression) of ARG1 associated with reprotox - general 1
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.75 Pain Relevance 0
Collectively, our results reveal that, although both induced by R1881, the signaling pathways leading to ARG1 and ARG2 expression differ for the two enzymes and need to be further examined.
Positive_regulation (leading) of Gene_expression (expression) of ARG1
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.75 Pain Relevance 0
Interestingly, although no significant changes were observed in ARG1 mRNA expression in LNCaP cells treated with R1881, ARG1 protein expression was significantly increased.
Positive_regulation (increased) of Gene_expression (expression) of ARG1
4) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.11 Pain Relevance 0
Following androgen stimulation of LNCaP cells with 10 nM R1881, both ARG1 and ARG2 were overexpressed.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of ARG1
5) Confidence 0.49 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920336 Disease Relevance 1.00 Pain Relevance 0
We did not observe any increases in ARG1 or ARG2 protein expression in DU145 and PC3 stimulated with 10 nM of R1881 (Figure S1B).


Neg (not) Positive_regulation (increases) of Gene_expression (expression) of ARG1
6) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.05 Pain Relevance 0.03
It is important to note that expression of ARG1 and ARG2 following IL-8 stimulation was not as substantial as with R1881 stimulation suggesting that other androgen-regulated pathways could be involved.
Positive_regulation (stimulation) of Gene_expression (expression) of ARG1
7) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.59 Pain Relevance 0.04
We also observed an induction of ARG2, but not ARG1, gene expression after a 24 hr stimulation (Figure S2C).
Positive_regulation (induction) of Gene_expression (expression) of ARG1
8) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.15 Pain Relevance 0
In the HS LNCaP cell line, androgen stimulation led to the increased expression of both ARG1 and ARG2 in an androgen receptor (AR) dependant manner.
Positive_regulation (led) of Gene_expression (expression) of ARG1
9) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.85 Pain Relevance 0.04
In the HS LNCaP cell line, androgen stimulation led to the increased expression of both ARG1 and ARG2 in an androgen receptor (AR) dependant manner.
Positive_regulation (increased) of Gene_expression (expression) of ARG1
10) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.85 Pain Relevance 0.04
Accordingly, the evidence that arginase 1 is aberrantly overexpressed in the lesional skin of psoriasis patients suggests the possibility that arginine, which is the substrate for NO generation by iNOS, might not be adequately available for iNOS activity [38].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of arginase 1 in skin associated with psoriasis
11) Confidence 0.13 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2929514 Disease Relevance 0.64 Pain Relevance 0.16
The 2 images were imported into Corel-Paint X3, version 13 and macrophage infiltrate assessed for expression of either iNOS or arginase I.


Positive_regulation (assessed) of Gene_expression (expression) of arginase in macrophage
12) Confidence 0.05 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017541 Disease Relevance 0.69 Pain Relevance 0.08
Overall, there appeared to be more arginase I expressing macrophages within the stroma of the polyps, when analysed as both the absolute number of arginase I positive cells and the percentage of arginase I positive cells within the total macrophage population, and this was statistically significant with p?
Positive_regulation (macrophages) of Gene_expression (expressing) of arginase in stroma associated with polyps
13) Confidence 0.05 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017541 Disease Relevance 1.14 Pain Relevance 0.04

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