INT326769

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 15
Disease Relevance 9.70
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ARG2) small molecule metabolic process (ARG2) cellular nitrogen compound metabolic process (ARG2)
ARG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 105 99.76 Very High Very High Very High
Inflammation 15 96.28 Very High Very High Very High
agonist 15 65.44 Quite High
palliative 15 65.08 Quite High
Disease Link Frequency Relevance Heat
Reprotox - General 1 810 99.84 Very High Very High Very High
Cancer 555 98.60 Very High Very High Very High
INFLAMMATION 15 96.28 Very High Very High Very High
Malignant Neoplastic Disease 150 93.88 High High
Recurrence 15 87.44 High High
Hyperplasia 60 87.24 High High
Breast Cancer 15 80.72 Quite High
Colon Cancer 15 79.12 Quite High
Toxicity 15 60.24 Quite High
Apoptosis 15 56.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on our in vitro data, we hypothesized that androgens might modulate ARG2 protein expression in PCa patients as well.
Spec (might) Regulation (modulate) of Gene_expression (expression) of ARG2 associated with reprotox - general 1
1) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.53 Pain Relevance 0.03
However, the regulation of arginase expression by PCa cells remains undefined.
Regulation (regulation) of Gene_expression (expression) of arginase associated with reprotox - general 1
2) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.73 Pain Relevance 0
Taken together, these results suggest that androgens regulate the expression of ARG2 in vivo in PCa patients as ADT reduces ARG2 expression.


Regulation (regulate) of Gene_expression (expression) of ARG2 associated with reprotox - general 1
3) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.58 Pain Relevance 0
The implication of an androgen-regulated expression of ARG1 and ARG2 in prostate carcinogenesis requires further investigation.
Regulation (regulated) of Gene_expression (expression) of ARG2
4) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.86 Pain Relevance 0
As arginases are well-documented to participate in the sculpting of the tumor immunological microenvironment [15] and that cytokines are known to induce arginase expression in murine models [16], we assessed whether cytokines could also regulate arginase expression in human PCa.
Regulation (regulate) of Gene_expression (expression) of arginase associated with cancer, reprotox - general 1 and cytokine
5) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.51 Pain Relevance 0.19
Our hypothesis was that androgens could regulate the expression of ARG2 by PCa cells.


Regulation (regulate) of Gene_expression (expression) of ARG2 associated with reprotox - general 1
6) Confidence 0.61 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920336 Disease Relevance 0.96 Pain Relevance 0
While the immunosuppressive properties of arginases through the metabolism of l-arginine are well documented (reviewed in [8]), the regulation of human arginase expression, however, is currently undefined.
Regulation (regulation) of Gene_expression (expression) of arginase
7) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.85 Pain Relevance 0.11
As our results suggest that androgens regulate arginase expression, we evaluated the contribution of the AR.
Regulation (regulate) of Gene_expression (expression) of arginase
8) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0 Pain Relevance 0.03
Androgen-regulated expression of ARG1 and ARG2
Regulation (Androgen) of Gene_expression (expression) of ARG2
9) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.70 Pain Relevance 0
Androgen-regulated expression of ARG1 and ARG2
Regulation (regulated) of Gene_expression (expression) of ARG2
10) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.70 Pain Relevance 0
Furthermore, in order to study whether ARG1 and ARG2 expression by LNCaP cells affected their immunosuppressive potential, PBMCs from healthy donors were activated in the presence of conditioned media from LNCaP+siCTRL or LNCaP+siARG1 or LNCaP+siARG2.
Spec (whether) Regulation (affected) of Gene_expression (expression) of ARG2
11) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.09 Pain Relevance 0
Our data demonstrate that androgens regulate the expression of both ARG1 and ARG2 in HS PCa cell lines and in PCa patients in an AR-dependent manner.
Regulation (regulate) of Gene_expression (expression) of ARG2 associated with reprotox - general 1
12) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.42 Pain Relevance 0.05
Gene expression analyses and murine studies suggest that androgens regulate the expression of ARG2 and other enzymes of the polyamine pathway [11], [12], [13].
Regulation (regulate) of Gene_expression (expression) of ARG2
13) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.77 Pain Relevance 0.10
The regulation of arginase expression following androgen stimulation was dependent on the androgen receptor (AR), as a siRNA treatment targeting the AR inhibited both ARG1 and ARG2 overexpression.
Regulation (regulation) of Gene_expression (expression) of arginase
14) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920336 Disease Relevance 0.99 Pain Relevance 0
Finally, we discovered that IL-8 was also regulated by androgens under the control of the AR, and participated in the regulation of ARG1 and ARG2 expression.
Regulation (regulation) of Gene_expression (expression) of ARG2
15) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 1.04 Pain Relevance 0.03

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