INT326773

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.89
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ARG2) small molecule metabolic process (ARG2) cellular nitrogen compound metabolic process (ARG2)
ARG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 42 89.20 High High
agonist 6 89.04 High High
palliative 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 6 99.12 Very High Very High Very High
Cancer 222 98.64 Very High Very High Very High
Hyperplasia 24 98.24 Very High Very High Very High
Reprotox - General 1 324 83.28 Quite High
Malignant Neoplastic Disease 60 57.68 Quite High
Breast Cancer 6 57.52 Quite High
Colon Cancer 6 55.92 Quite High
Recurrence 6 16.72 Low Low
Apoptosis 6 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both the ARG1 and ARG2 induction following R1881 stimulation were inhibited by the siRNA treatment, which translated in the absence of an upregulation in arginase activity (Figure 2F).
Positive_regulation (induction) of ARG2
1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.19 Pain Relevance 0.04
The androgen induction of ARG2 was not blocked, even at the highest concentration of bicalutamide.
Positive_regulation (induction) of ARG2
2) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0 Pain Relevance 0.04
In a proliferation assay with EGF instead of R1881, no ARG2 induction was observed (data not shown).
Neg (no) Positive_regulation (induction) of ARG2
3) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.70 Pain Relevance 0
Both the ARG1 and ARG2 induction following R1881 stimulation were inhibited by the siRNA treatment, which translated in the absence of an upregulation in arginase activity (Figure 2F).
Positive_regulation (upregulation) of arginase
4) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.39 Pain Relevance 0.03
We also observed an induction of ARG2, but not ARG1, gene expression after a 24 hr stimulation (Figure S2C).
Positive_regulation (induction) of ARG2
5) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.15 Pain Relevance 0
IL-8 induction of ARG1 and ARG2 expression
Neg (No) Positive_regulation (induction) of ARG2
6) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.45 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox