INT326778

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Context Info
Confidence 0.58
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 7.05
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ARG2) small molecule metabolic process (ARG2) cellular nitrogen compound metabolic process (ARG2)
Anatomy Link Frequency
22RV1 2
ARG2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 11 57.44 Quite High
cytokine 77 5.00 Very Low Very Low Very Low
palliative 11 5.00 Very Low Very Low Very Low
Inflammation 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 594 99.84 Very High Very High Very High
Cancer 407 98.84 Very High Very High Very High
Malignant Neoplastic Disease 110 97.08 Very High Very High Very High
Hyperplasia 44 96.96 Very High Very High Very High
Toxicity 11 45.40 Quite Low
Apoptosis 11 5.00 Very Low Very Low Very Low
Breast Cancer 11 5.00 Very Low Very Low Very Low
INFLAMMATION 11 5.00 Very Low Very Low Very Low
Colon Cancer 11 5.00 Very Low Very Low Very Low
Recurrence 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared to a siCTRL, both siRNA significantly inhibited ARG1 or ARG2 expression (Figure 4A).
Negative_regulation (inhibited) of Gene_expression (expression) of ARG2
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.49 Pain Relevance 0
Taken together, these results suggest that androgens regulate the expression of ARG2 in vivo in PCa patients as ADT reduces ARG2 expression.


Negative_regulation (reduces) of Gene_expression (expression) of ARG2 associated with reprotox - general 1
2) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.57 Pain Relevance 0
By HPLC, we then determined the impact of the inhibition of ARG1 and ARG2 expression on the metabolism of l-arginine by LNCaP cells.
Negative_regulation (inhibition) of Gene_expression (expression) of ARG2
3) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.44 Pain Relevance 0
Diminished ARG2 expression in PCa patients following ADT
Negative_regulation (Diminished) of Gene_expression (expression) of ARG2 associated with reprotox - general 1
4) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.49 Pain Relevance 0.03
These results corroborate published data describing a lower ARG2 expression in androgen-insensitive PCa cell lines (DU145 and PC3) and in the tumor and HR tissues of PCa patients [6], [19].
Negative_regulation (lower) of Gene_expression (expression) of ARG2 associated with cancer and reprotox - general 1
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 1.41 Pain Relevance 0
The decreased ARG1 and ARG2 expression also translated with diminished LNCaP cells cell growth and increased PBMC activation following exposure to LNCaP cells conditioned media.
Negative_regulation (decreased) of Gene_expression (expression) of ARG2
6) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920336 Disease Relevance 0.61 Pain Relevance 0
The regulation of arginase expression following androgen stimulation was dependent on the androgen receptor (AR), as a siRNA treatment targeting the AR inhibited both ARG1 and ARG2 overexpression.
Negative_regulation (inhibited) of Gene_expression (overexpression) of ARG2
7) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920336 Disease Relevance 0.95 Pain Relevance 0
To evaluate whether ARG1 and ARG2 expressed by LNCaP cells were metabolically active, we inhibited the expression of either ARG1 or ARG2 by siRNA.
Negative_regulation (inhibited) of Gene_expression (expression) of ARG2
8) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.52 Pain Relevance 0
We also observed that androgen deprivation in vitro could decrease ARG2, but not ARG1 protein expression, in LNCaP and 22RV1 cells cultured for seven days in the absence of androgens (Figure 3B).
Neg (not) Negative_regulation (decrease) of Gene_expression (expression) of ARG2 in 22RV1
9) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.61 Pain Relevance 0
Reciprocally, androgen deprivation and ADT reduced ARG2 expression in vitro and in the primary tumor of PCa patients, respectively.
Negative_regulation (reduced) of Gene_expression (expression) of ARG2 associated with cancer and reprotox - general 1
10) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.87 Pain Relevance 0
We observed that inhibition of either ARG1 or ARG2 expression resulted in a lower proliferation of LNCaP cells maintained in complete media (p?
Negative_regulation (inhibition) of Gene_expression (expression) of ARG2
11) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.10 Pain Relevance 0

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