INT326816

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 3.96
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
spinal cord 2
Tlr4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 37 99.68 Very High Very High Very High
intrathecal 6 99.12 Very High Very High Very High
Inflammatory mediators 12 97.20 Very High Very High Very High
Spinal cord 12 96.72 Very High Very High Very High
Neuropathic pain 18 95.12 Very High Very High Very High
cytokine 47 92.00 High High
Inflammation 102 89.52 High High
Pain 9 88.88 High High
chung model 1 84.08 Quite High
withdrawal 7 79.28 Quite High
Disease Link Frequency Relevance Heat
Injury 39 99.68 Very High Very High Very High
Sepsis 189 99.52 Very High Very High Very High
Insulin Resistance 60 97.76 Very High Very High Very High
INFLAMMATION 127 97.20 Very High Very High Very High
Neuropathic Pain 31 95.12 Very High Very High Very High
Obesity 60 92.08 High High
Pain 12 88.88 High High
Hyperalgesia 10 75.28 Quite High
Hypoglycemia 9 58.92 Quite High
Nociception 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
in spinal cord tissues was significantly lower in the CCI group during the course of TLR4-siRNA treatment, indicating that intrathecal administration of TLR4-siRNA significantly attenuated TLR4 induction in the CCI rats (Figure 3).


Negative_regulation (attenuated) of Positive_regulation (induction) of TLR4 in spinal cord associated with eae, intrathecal and spinal cord
1) Confidence 0.59 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2920570 Disease Relevance 1.41 Pain Relevance 1.38
Fig. 3 shows that sepsis induced TLR4 protein levels and activation, as demonstrated by an increase in TLR4/MyD88 interaction in the three tissues investigated, and atorvastatin reduced this early step of TLR4 activation and also TLR4 expression (Fig. 3A–C).
Negative_regulation (reduced) of Positive_regulation (activation) of TLR4 associated with sepsis
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.87 Pain Relevance 0.20
This drug reduces TLR4 activation, in association with downstream JNK and IKK/NF-?
Negative_regulation (reduces) of Positive_regulation (activation) of TLR4
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.98 Pain Relevance 0.26
Our data show that atorvastatin decreases TLR4 expression/activation, a modulation that might have a role in the attenuated expression of inflammatory mediators in response to a septic insult.
Negative_regulation (decreases) of Positive_regulation (activation) of TLR4 associated with inflammatory mediators
4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.70 Pain Relevance 0.12

General Comments

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