INT326820

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.27
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Cdk5) cytoplasm (Cdk5) cytosol (Cdk5)
nucleocytoplasmic transport (Cdk5) cell death (Cdk5) nucleolus (Cdk5)
Anatomy Link Frequency
brain 2
Cdk5 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 72 99.56 Very High Very High Very High
Inflammation 12 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Glutamate receptor 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Intracerebroventricular 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 42 99.56 Very High Very High Very High
Death 72 80.84 Quite High
Transient Ischemic Attack 3 80.32 Quite High
Stroke 81 79.76 Quite High
Brain Hemorrhage 15 60.80 Quite High
Injury 18 59.16 Quite High
Cv General 4 Under Development 15 50.32 Quite High
Myelodysplastic Syndromes 21 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data revealed that the transient increase of CDK5 activity previously observed in the ischemic ipsilateral brain hemisphere was significantly prevented by in vivo treatment with (S)-roscovitine (Figure 4D).


Negative_regulation (prevented) of Positive_regulation (increase) of CDK5 in brain
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.45 Pain Relevance 0.07
Our in vivo data revealed that this increase in CDK5 activity was prevented by the systemic administration of (S)-roscovitine, supporting the hypothesis that CDK5 is involved in its neuroprotective effects.
Negative_regulation (prevented) of Positive_regulation (increase) of CDK5
2) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.37 Pain Relevance 0.12
Cerebral increase of CDK5/p25 activity was observed 3 hrs after the insult and prevented by systemic (S)-roscovitine administration.
Negative_regulation (prevented) of Positive_regulation (increase) of CDK5
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920814 Disease Relevance 0.45 Pain Relevance 0.09

General Comments

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