INT326879

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 2.21
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PLD2) plasma membrane (PLD2) nucleus (PLD2)
cytoskeleton organization (PLD2)
PLD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 7 73.20 Quite High
agonist 7 22.88 Low Low
cINOD 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 231 99.42 Very High Very High Very High
Sarcoma 7 98.34 Very High Very High Very High
Cancer 168 95.60 Very High Very High Very High
Breast Cancer 28 78.64 Quite High
Familial Adenomatous Polyposis 21 69.52 Quite High
Metastasis 14 68.08 Quite High
Pathologic Processes 7 21.72 Low Low
Glioma 7 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, we found that TCF binding sites on the PLD2 promoter are conserved across species (Figure 4F).
PLD2 Binding (binding) of
1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.05 Pain Relevance 0
Ewing's sarcoma fusion protein, EWS/Fli, has been reported to induce selective PLD2 expression by binding to the ETS domain of the PLD2 promoter [39].
PLD2 Binding (binding) of associated with sarcoma
2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.35 Pain Relevance 0
Elevated expression of PLD1 and PLD2 has been reported in colorectal cancer tissues [9]; in particular, PLD2 expression level and its association with clinicopathological features have recently been investigated in colorectal carcinoma [10].
PLD2 Binding (association) of associated with colon cancer
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.97 Pain Relevance 0.04
Using site-directed mutagenesis and the ChIP assay, we were able to define two functional TCF binding sites on the PLD2 promoter, suggesting that the PLD2 gene is a direct transcriptional target of ?
PLD2 Binding (binding) of
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.37 Pain Relevance 0
LiCl was injected into mice, and expression of PLD was investigated in several tissues using anti-PLD antibody which recognizes both PLD1 and PLD2.
PLD2 Binding (recognizes) of
5) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.38 Pain Relevance 0
The polyclonal anti-PLD antibody that recognizes both PLD1 and PLD2 was generated as previously described [18].


PLD2 Binding (recognizes) of
6) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0 Pain Relevance 0
Anti-PLD antibody was generated against C-terminal peptide of PLD1 in which 7 amino acids among 12 amino acids were the same with that of PLD2, and recognizes both PLD1 and PLD2 [18].
PLD2 Binding (recognizes) of
7) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920823 Disease Relevance 0.08 Pain Relevance 0

General Comments

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