INT32692

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Context Info
Confidence 0.35
First Reported 1988
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 33
Total Number 33
Disease Relevance 13.29
Pain Relevance 9.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aif1) cytoplasm (Aif1)
Anatomy Link Frequency
microglia 5
dorsal horn 3
Notch 2
spinal cord 2
whiskers 2
Aif1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 167 100.00 Very High Very High Very High
Inflammation 137 100.00 Very High Very High Very High
antagonist 47 100.00 Very High Very High Very High
Analgesic 21 100.00 Very High Very High Very High
Calcium channel 12 100.00 Very High Very High Very High
Cannabinoid 1 100.00 Very High Very High Very High
Spinal cord 152 99.66 Very High Very High Very High
trigeminal ganglion 20 99.46 Very High Very High Very High
Pain 241 99.44 Very High Very High Very High
Neuropathic pain 94 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 161 100.00 Very High Very High Very High
Cardiovascular Disease 9 99.52 Very High Very High Very High
Ganglion Cysts 59 99.46 Very High Very High Very High
Hypertension 13 99.46 Very High Very High Very High
Neuropathic Pain 285 99.44 Very High Very High Very High
Pain 278 99.44 Very High Very High Very High
Ocular Hypertension 282 99.14 Very High Very High Very High
Cancer 188 98.16 Very High Very High Very High
Pathologic Constriction 3 97.60 Very High Very High Very High
Bordatella Infection 9 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably, in PVG rats higher mRNA expression of Toll-like receptors (Tlr) -2 and -9, together with increased staining for Iba1/ED1 was detected in the whiskers area.
Positive_regulation (increased) of Iba1 in whiskers
1) Confidence 0.35 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2929186 Disease Relevance 1.09 Pain Relevance 0
These included increases in Iba1 and OX-42 labeling (markers of microglia), hypertrophic morphology, the thickness and the retraction of processes, and in the number of activated microglia cells.
Positive_regulation (increases) of Iba1 in microglia
2) Confidence 0.35 Published 2008 Journal Glia Section Abstract Doc Link 18186080 Disease Relevance 1.36 Pain Relevance 0.93
Because IBA-1 activation coincided with an increase in TH and Notch-3 expression in the presence of mildronate, microglial activation may have a beneficial role in cell survival.
Positive_regulation (activation) of IBA-1 in Notch
3) Confidence 0.33 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000094 Disease Relevance 0.35 Pain Relevance 0.15
In nerve injured animals, Iba-1 staining was significantly increased in the trigeminal nuclear complex, especially in the principal sensory nucleus (Pr5) and subnucleus caudalis (Sp5C) area (Figure 2).
Positive_regulation (increased) of Iba-1 in Pr5
4) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992508 Disease Relevance 0.20 Pain Relevance 0.23
In the whiskers area of DA rats from 2 dpi there was lower and delayed activation of Iba1+ (Figure 4C) and ED1+ (Figure 4M) (asterisk in Figure 3C, 3E, 4E), as well as of CD11b/c+ cells (Table1) compared to the PVG rats (asterisk in Figure 3D and 3F), despite the fact that more HSV-1 staining was visible in this area in DA rats.
Positive_regulation (activation) of Iba1 in whiskers associated with cold sores
5) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.43 Pain Relevance 0
In the contralateral spinal dorsal horn, GFAP-positive astrocytes significantly increased for 21 days, but Iba-1 was not significant.
Positive_regulation (increased) of Iba-1 in spinal
6) Confidence 0.30 Published 2008 Journal Spine Section Body Doc Link 18496347 Disease Relevance 0 Pain Relevance 0
In the present study, we also assessed the microglial marker IBA-1, which is specifically expressed in macrophages/microglia and is upregulated when these cells are activated [52].
Positive_regulation (upregulated) of IBA-1 in microglia
7) Confidence 0.29 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000094 Disease Relevance 0.70 Pain Relevance 0.15
In this group the level of Iba-1 immunoreactivity in the ipsilateral dorsal horn was substantially increased particularly in the medial portion within the somatotopic area associated with sciatic nerve termination at the 24 h (data not shown) and 48 h time points.
Positive_regulation (increased) of Iba-1 in sciatic nerve associated with dorsal horn and sciatic nerve
8) Confidence 0.29 Published 2009 Journal Pain Section Body Doc Link PMC2702711 Disease Relevance 0 Pain Relevance 0.76
In both the groups, levels of Iba-1 expression were low except for a localized increase in Iba-1 immunoreactivity in the dorsal laminae of the ipsilateral side in the lateral L3/4 segments corresponding to the termination site of afferents damaged by the surgical incision to expose the sciatic nerve in the upper leg (Fig. 2).
Neg (except) Positive_regulation (increase) of Iba-1 in lateral associated with sciatic nerve
9) Confidence 0.29 Published 2009 Journal Pain Section Body Doc Link PMC2702711 Disease Relevance 0 Pain Relevance 1.02
Iba1 staining was increased in the ipsilateral dorsal horn 14 days after cancer cell inoculation of the femur (Figs. 4A, B).
Positive_regulation (increased) of Iba1 in dorsal horn associated with cancer and dorsal horn
10) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966439 Disease Relevance 0.53 Pain Relevance 0.20
In the spinal cord, a considerable increase in IBA1 immunoreactivity (microglia) was observed after PSNL on the ipsilateral side of both the dorsal and the ventral horns, as compared to the contralateral uninjured side and normal controls (Figure 3A).
Positive_regulation (increase) of IBA1 in spinal cord associated with spinal cord
11) Confidence 0.27 Published 2011 Journal Mol Pain Section Body Doc Link PMC3022745 Disease Relevance 0.17 Pain Relevance 0.05
Interestingly this also extended to the lateral dorsal horn where the increase in Iba-1 immunoreactivity seen in the adult that is associated with the surgical incision was also absent in both the stimulated and sham groups (Fig. 6B).
Positive_regulation (increase) of Iba-1 in lateral associated with dorsal horn
12) Confidence 0.27 Published 2009 Journal Pain Section Body Doc Link PMC2702711 Disease Relevance 0.30 Pain Relevance 0.60
Importantly, treatment with fluorocitrate or minocycline reversed and normalized the enhanced Iba-1 immunoreactivity in STZ spinal cord microglia (Figure 3-B).
Positive_regulation (enhanced) of Iba-1 in spinal cord associated with spinal cord
13) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.54 Pain Relevance 0.65
Iba1 fluorescence intensity was increased by 36% in the ipsilateral dorsal horn in comparison to its contralateral counterpart (p<0.05) and by 44% when compared to sham animals (p<0.05; Table 1).
Positive_regulation (increased) of Iba1 in dorsal horn associated with dorsal horn
14) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2966439 Disease Relevance 0.52 Pain Relevance 0.21
Ten-micron-thick tissue sections were stained to visualize the cells that were positive for TH, ubiquitin, Notch-3, IBA-1, GFAP and iNOS, according to a previously described immunohistochemical procedure [40].
Positive_regulation (positive) of IBA-1 in Notch
15) Confidence 0.22 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000094 Disease Relevance 0 Pain Relevance 0.13
Unfortunately, many studies defined microglial activation only based on altered expression of Iba1 or OX-42 (CD11b), which lead to controversies when trying to link microglial activation and pain states, because the direct role of Iba1 and CD11b in neuropathic pain genesis is unclear.
Positive_regulation (role) of Iba1 associated with pain and neuropathic pain
16) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759920 Disease Relevance 0.94 Pain Relevance 0.90
After PDGF-BB (10 pmol) administration, the number of Iba1-positive cells in the dorsal horn was significantly increased on day 3 and day 7 compared with vehicle-treated controls (P < 0.01) (Figure 3A, B).
Positive_regulation (increased) of Iba1 in dorsal horn associated with dorsal horn
17) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.14 Pain Relevance 0.42
An increase in the number of IBA-1-positive cells was found in the 6-OHDA-lesioned striatum in comparison to the control group (23 ± 3 vs. 12 ± 2 cells/mm2, p = 0.03; Figure 11A).
Positive_regulation (increase) of IBA-1-positive in striatum
18) Confidence 0.20 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC3000094 Disease Relevance 0 Pain Relevance 0
Iba1-positive microglia in the dorsal horns of PDGF-BB-administered rats also showed an increase in Iba1 labeling and a tendency toward a hypertrophied morphology (Figure 3C).
Positive_regulation (increase) of Iba1 in microglia
19) Confidence 0.16 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.15 Pain Relevance 0.44
At 4 weeks under the ocular hypertension, microglia in the LBP-fed rats (b) showed increased iba-1 immunoreactivity in the soma and certain enlarged long processes.
Positive_regulation (increased) of iba-1 in microglia associated with ocular hypertension
20) Confidence 0.15 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723674 Disease Relevance 0.66 Pain Relevance 0

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