INT326929

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.67
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Unc79) cellular_component (Unc79) biological_process (Unc79)
Anatomy Link Frequency
brain 1
Unc79 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 6 100.00 Very High Very High Very High
Neurotransmitter 3 78.40 Quite High
substance P 12 76.96 Quite High
tetrodotoxin 3 74.84 Quite High
halothane 24 62.56 Quite High
Eae 33 34.08 Quite Low
alcohol 24 24.20 Low Low
Dopamine 9 8.80 Low Low
isoflurane 21 5.00 Very Low Very Low Very Low
Ventral tegmentum 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Helminth Infection 6 93.48 High High
Syncope 3 93.08 High High
Body Weight 21 90.44 High High
Sprains And Strains 78 89.12 High High
Targeted Disruption 12 81.48 Quite High
Nash(non-alcoholic Steatohepatitis) 3 58.60 Quite High
Disease 9 39.36 Quite Low
Alcohol Addiction 12 30.56 Quite Low
Hypersensitivity 24 5.00 Very Low Very Low Very Low
Decompression Sickness 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the protein expression of these gene products is interdependent, i.e. disruption of unc-79 or unc-80 also yields lower or absent expression of NALCN orthologs and vice versa, leading to the hypothesis that they function as a complex [10]–[14].
Negative_regulation (disruption) of unc-79
1) Confidence 0.42 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2920847 Disease Relevance 0.33 Pain Relevance 0.21
Northern blot and in situ hybridizations indicate that the unc-79 mRNA is widely expressed throughout the central nervous system, and as expected there is a modest reduction in mRNA in homozygous mutant P0 brain tissue, presumably due to nonsense mediated decay (Figure S1).
Negative_regulation (reduction) of unc-79 in brain associated with central nervous system
2) Confidence 0.42 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2920847 Disease Relevance 0.18 Pain Relevance 0.05
Since unc-79 mRNA is reduced in Lwt/+ mice, the response of Lightweight heterozygotes to ethanol and inhaled anesthetics was examined.
Negative_regulation (reduced) of unc-79
3) Confidence 0.41 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2920847 Disease Relevance 0.16 Pain Relevance 0

General Comments

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