INT32693

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Context Info
Confidence 0.42
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.70
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car3) cytoplasm (Car3)
Anatomy Link Frequency
bars 2
dentate gyrus 2
CAR 2
cortex 2
hippocampus 2
Car3 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 105 99.68 Very High Very High Very High
Inflammation 153 98.32 Very High Very High Very High
GABAergic 24 92.08 High High
ketamine 5 90.48 High High
Pyramidal cell 105 89.12 High High
Central nervous system 42 80.48 Quite High
Chronic pancreatitis 2 73.12 Quite High
antagonist 17 71.76 Quite High
Intracerebroventricular 9 53.68 Quite High
Inflammatory response 20 51.04 Quite High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 257 100.00 Very High Very High Very High
Pancreatic Cancer 3 98.84 Very High Very High Very High
Disease 26 98.68 Very High Very High Very High
Sprains And Strains 48 98.62 Very High Very High Very High
INFLAMMATION 181 98.32 Very High Very High Very High
Carcinoma 4 96.40 Very High Very High Very High
Gliosis 46 95.12 Very High Very High Very High
Death 23 86.72 High High
Urological Neuroanatomy 3 85.28 High High
Breast Cancer 1 83.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum levels of CAR-3 were significantly increased in 51% of the patients with pancreatic carcinomas, in 60% of patients with biliary tract carcinomas and in about 15% of the patients with carcinomas of the digestive apparatus.
Positive_regulation (increased) of Gene_expression (levels) of CAR-3 in CAR associated with pancreatic cancer and carcinoma
1) Confidence 0.42 Published 1988 Journal Int. J. Biol. Markers Section Abstract Doc Link 2977786 Disease Relevance 1.22 Pain Relevance 0.12
Between mouse strains, oscillation frequency in CA1 showed similar differences as was the case for CA3 (NOD: 19.7?
Positive_regulation (for) of Gene_expression (case) of CA3 associated with sprains and strains
2) Confidence 0.39 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0.24 Pain Relevance 0.37
Two single guide cannulae (Plastics One, Roanoke, VA, USA) were implanted into the CA3 region of the hippocampus bilaterally (stereotaxic coordinates: AP?
Positive_regulation (into) of Gene_expression (region) of CA3 in hippocampus associated with hippocampus
3) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0 Pain Relevance 0.10
Expression levels of calpain tended to be increased in the cortex and CA3 of A?
Positive_regulation (increased) of Gene_expression (cortex) of CA3 in cortex
4) Confidence 0.18 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.09 Pain Relevance 0
We found that intraventricular infusion of activin A increased the number of newborn neurons in the dentate gyrus, CA3, and CA1 layers of the normal adult hippocampus and also, following lipopolysaccharide administration, had a potent inhibitory effect on gliosis in vivo and on microglial proliferation in vivo and in vitro.
Positive_regulation (increased) of Gene_expression (layers) of CA3 in dentate gyrus associated with hippocampus and gliosis
5) Confidence 0.16 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Abstract Doc Link PMC2733378 Disease Relevance 0.72 Pain Relevance 0.19
(D): There was, however, increased neurogenesis in the DG, CA3, and CA1 regions of the dorsal intact hippocampus in activin A-treated animals (n = 10, gray bars), whereas (FS-288)-treated animals had no effect on neurogenesis (n = 10, black bars) compared to controls (n = 10, white bars).
Positive_regulation (increased) of Gene_expression (regions) of CA3 in bars associated with hippocampus and neurodegenerative disease
6) Confidence 0.16 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.43 Pain Relevance 0.11

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