INT32694

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Context Info
Confidence 0.06
First Reported 1988
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.18
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUCL1)
Anatomy Link Frequency
endothelial cells 1
CAR 1
platelets 1
lamina 1
MUCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 86.80 High High
Bile 8 64.16 Quite High
Chronic pancreatitis 2 52.08 Quite High
palliative 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
endometriosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 6 99.44 Very High Very High Very High
Solid Tumor 2 97.74 Very High Very High Very High
Adhesions 8 94.00 High High
Cancer 57 88.60 High High
Apoptosis 29 87.52 High High
INFLAMMATION 2 86.80 High High
Disease 5 85.76 High High
Cholangiocarcinoma 38 84.88 Quite High
Death 4 80.48 Quite High
Pancreatic Cancer 5 76.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, CD24 has been described in a wide variety of malignancies and shown to be a prognostic marker in several solid tumors including colorectal, stomach, lung, prostate, ovarian, and breast.16–21 CD24 is a small, heavily glycosylated, mucin-like, cell-surface protein expressed in developing cells including pre-B cells, keratinocytes, and renal tubular epithelium.22–24 It functions as an alternative ligand of P-selectin, an adhesion receptor expressed on activated endothelial cells and platelets which can enhance the metastatic potential of CD24-expressing tumor cells.25–28 CD24 has apoptotic activity, and its cross-linking induces the sustained activation of p38 MAPK (mitogen-activated protein kinases)—the magnitude of which may determine the survival or death of pre-B cells.29 An improved understanding of the molecular pathways involved in the pathogenesis and progression of cholangiocarcinoma will contribute to the development of targeted therapy.
Gene_expression (expressed) of mucin-like in platelets associated with cholangiocarcinoma, cancer, solid tumor, apoptosis, death and adhesions
1) Confidence 0.06 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 1.11 Pain Relevance 0.03
CD68 epitope of MDC, mucin-like molecule belonging to the lysosomal-associated membrane protein family [26], was expressed by MDC in the lamina propria (Fig. 2C).
Gene_expression (expressed) of mucin-like molecule in lamina
2) Confidence 0.02 Published 2001 Journal BMC Dev Biol Section Body Doc Link PMC34117 Disease Relevance 0.08 Pain Relevance 0
Recently, CD24 has been described in a wide variety of malignancies and shown to be a prognostic marker in several solid tumors including colorectal, stomach, lung, prostate, ovarian, and breast.16–21 CD24 is a small, heavily glycosylated, mucin-like, cell-surface protein expressed in developing cells including pre-B cells, keratinocytes, and renal tubular epithelium.22–24 It functions as an alternative ligand of P-selectin, an adhesion receptor expressed on activated endothelial cells and platelets which can enhance the metastatic potential of CD24-expressing tumor cells.25–28 CD24 has apoptotic activity, and its cross-linking induces the sustained activation of p38 MAPK (mitogen-activated protein kinases)—the magnitude of which may determine the survival or death of pre-B cells.29 An improved understanding of the molecular pathways involved in the pathogenesis and progression of cholangiocarcinoma will contribute to the development of targeted therapy.
Gene_expression (expressed) of mucin-like in endothelial cells associated with cholangiocarcinoma, cancer, solid tumor, apoptosis, death and adhesions
3) Confidence 0.02 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 1.11 Pain Relevance 0.03
The monoclonal antibody-defined CAR-3 antigen is a new carcinoma associated marker which is expressed on a mucin-like molecule.
Gene_expression (expressed) of mucin-like molecule in CAR associated with carcinoma
4) Confidence 0.01 Published 1988 Journal Int. J. Biol. Markers Section Abstract Doc Link 2977786 Disease Relevance 0.89 Pain Relevance 0.10

General Comments

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