INT327

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Context Info
Confidence 0.53
First Reported 1976
Last Reported 2005
Negated 2
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 4.22
Pain Relevance 10.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gnrhr) signal transducer activity (Gnrhr)
Anatomy Link Frequency
plasma 10
blood 4
Gnrhr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 46 100.00 Very High Very High Very High
agonist 15 100.00 Very High Very High Very High
narcan 11 100.00 Very High Very High Very High
opiate 5 100.00 Very High Very High Very High
Pain 5 100.00 Very High Very High Very High
noradrenaline 2 100.00 Very High Very High Very High
Morphine 19 99.74 Very High Very High Very High
antagonist 10 99.70 Very High Very High Very High
fluoxetine 1 99.02 Very High Very High Very High
Cancer pain 3 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 5 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 5 100.00 Very High Very High Very High
Hypothermia 3 100.00 Very High Very High Very High
Stress 3 99.98 Very High Very High Very High
Sleep Disorders 1 99.08 Very High Very High Very High
Cancer Pain 3 98.80 Very High Very High Very High
Panic Disorder 5 98.28 Very High Very High Very High
Agoraphobia 2 97.56 Very High Very High Very High
Hyperglycemia 7 96.56 Very High Very High Very High
Dysmenorrhea 2 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apomorphine did not produce a statistically significant increase in plasma growth hormone concentration when administered directly into the the third ventricle, and pimozide failed to abolish the increase in plasma growth hormone produced by L-dopa.
Neg (failed) Negative_regulation (abolish) of Positive_regulation (increase) of plasma growth hormone in plasma
1) Confidence 0.53 Published 1976 Journal Neuroscience Section Abstract Doc Link 11370235 Disease Relevance 0 Pain Relevance 0.33
The increase in plasma growth hormone concentration produced by intravenous L-dopa and clonidine was prevented by administration of phentolamine or phenoxybenzamine directly into the third ventricle.
Negative_regulation (prevented) of Positive_regulation (increase) of plasma growth hormone in plasma associated with clonidine
2) Confidence 0.53 Published 1976 Journal Neuroscience Section Abstract Doc Link 11370235 Disease Relevance 0 Pain Relevance 0.36
Administration of the dopaminergic agonists bromocriptine and L-dopa or the alpha-adrenergic receptor blocker phenoxybenzamine elevated GnRH-R acutely from average basal values of 240 +/- 22 and 254 +/- 21 fmol/mg protein to maximal values of 374 +/- 49, 441 +/- 67 and 461 +/- 75 fmol/mg, respectively, whereas the alpha-adrenergic agonist clonidine transiently decreased GnRH-R to 186 +/- 19 fmol/mg.
Negative_regulation (decreased) of Positive_regulation (elevated) of GnRH-R associated with agonist and clonidine
3) Confidence 0.43 Published 1985 Journal Endocrinology Section Abstract Doc Link 2857637 Disease Relevance 0 Pain Relevance 1.04
Similarly, chronic treatment with 5-HT uptake-inhibiting antidepressants such as fluoxetine, clomipramine and imipramine also significantly attenuated clonidine-induced increases in growth hormone levels.
Negative_regulation (attenuated) of Positive_regulation (increases) of growth hormone associated with antidepressant, clonidine and fluoxetine
4) Confidence 0.41 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 8145893 Disease Relevance 0 Pain Relevance 0.81
In contrast, pretreatment with the non-selective 5-HT1/2 antagonist, metergoline, and the 5-HT1C/5-HT2-selective antagonist, mesulergine, reduced clonidine-induced increases in growth hormone levels 81 to 87% without affecting clonidine-induced decreases in locomotor activity.
Negative_regulation (reduced) of Positive_regulation (increases) of growth hormone associated with eae, antagonist and clonidine
5) Confidence 0.37 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1356149 Disease Relevance 0.27 Pain Relevance 1.27
The mechanism through which cholinergic agonists act to inhibit opiate agonist stimulation of growth hormone is presently unknown.
Negative_regulation (inhibit) of Positive_regulation (stimulation) of growth hormone associated with agonist and opiate
6) Confidence 0.35 Published 1980 Journal Fed. Proc. Section Abstract Doc Link 6247214 Disease Relevance 0 Pain Relevance 1.44
Treatment with phenytoin resulted in a significant increase in growth hormone release after diazepam and glucagon, whilst sodium valproate reduced the growth hormone response to diazepam.
Negative_regulation (reduced) of Positive_regulation (response) of growth hormone
7) Confidence 0.34 Published 1989 Journal Epilepsy Res. Section Abstract Doc Link 2492934 Disease Relevance 0.34 Pain Relevance 0.19
In comparison to saline infusion, L-Arginine significantly reduced the number of contractions, together with an increase of both serum growth hormone and nitrates levels.
Negative_regulation (reduced) of Positive_regulation (increase) of serum growth hormone
8) Confidence 0.33 Published 1996 Journal J Perinat Med Section Abstract Doc Link 8827578 Disease Relevance 0.27 Pain Relevance 0.17
Acute immobilization stress suppresses naloxone- and N-methyl-d-aspartate (NMDA)-induced, but not gonadotropin-releasing hormone (GnRH)-induced, luteinizing hormone (LH) release in ovariectomized oestrogen-primed rats.
Negative_regulation (suppresses) of Neg (not) Positive_regulation (-induced) of gonadotropin-releasing hormone associated with stress and narcan
9) Confidence 0.27 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716406 Disease Relevance 0.25 Pain Relevance 0.20
The acute hyperglycemic effect of KX in fed rats was associated with decreased plasma levels of insulin, adrenocorticotropic hormone (ACTH), and corticosterone and increased levels of glucagon and growth hormone (GH).
Negative_regulation (decreased) of Positive_regulation (increased) of growth hormone in plasma
10) Confidence 0.20 Published 2005 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 16246906 Disease Relevance 0.55 Pain Relevance 0.32
After clonidine there was a decrease in plasma levels of noradrenaline and adrenaline, and an increase in growth hormone.
Negative_regulation (decrease) of Positive_regulation (increase) of growth hormone in plasma associated with noradrenaline and clonidine
11) Confidence 0.17 Published 1992 Journal Clin. Auton. Res. Section Abstract Doc Link 1323363 Disease Relevance 0.09 Pain Relevance 0.60
The results indicate that activation of opiate receptors in the brain produced pain relief, hypothermia (due to cutaneous vasodilation and sweating), and increased blood levels of prolactin, growth hormone and glucose in patients with cancer pain.
Negative_regulation (produced) of Positive_regulation (increased) of growth hormone in blood associated with pain, hypothermia, cancer pain, opiate and increased venous pressure under development
12) Confidence 0.13 Published 1987 Journal J. Neurol. Section Abstract Doc Link 3430186 Disease Relevance 1.05 Pain Relevance 1.41
During physical exercise a decrease in insulin and an increase in growth hormone was seen.
Negative_regulation (decrease) of Positive_regulation (increase) of growth hormone
13) Confidence 0.07 Published 1989 Journal Scand J Rehabil Med Section Abstract Doc Link 2652278 Disease Relevance 0.33 Pain Relevance 0.25
Clonidine produced significantly greater decreases in plasma MHPG levels and sitting and standing diastolic blood pressure and significantly smaller increases in growth hormone levels and self-rated drowsiness in the patients.
Negative_regulation (decreases) of Positive_regulation (increases) of growth hormone in blood associated with sleep disorders and clonidine
14) Confidence 0.05 Published 1986 Journal Arch. Gen. Psychiatry Section Abstract Doc Link 3021083 Disease Relevance 0.75 Pain Relevance 0.41
It was found that morphine anaesthesia blocked the increase in ACTH, cortisol, growth hormone, cyclic AMP, and glucose during surgery.
Negative_regulation (blocked) of Positive_regulation (increase) of growth hormone associated with morphine
15) Confidence 0.04 Published 1978 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 31757 Disease Relevance 0 Pain Relevance 0.52
Intracarotid clonidine, 2 microgram/kg, decreased plasma ACTH and corticoids and increased plasma growth hormone, whereas the same dose had no effect on these hormones when given intravenously or when given intravertebrally after occlusion of the basilar artery.
Negative_regulation (decreased) of Positive_regulation (increased) of plasma growth hormone in plasma associated with clonidine
16) Confidence 0.03 Published 1980 Journal Neuroendocrinology Section Abstract Doc Link 6248808 Disease Relevance 0.09 Pain Relevance 0.61
Significant decreases in basal and arginine-stimulated serum growth hormone and serum IGF-I were noted.
Negative_regulation (decreases) of Positive_regulation (arginine-stimulated) of serum growth hormone
17) Confidence 0.00 Published 1989 Journal Anticancer Res. Section Abstract Doc Link 2817814 Disease Relevance 0.25 Pain Relevance 0.27

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