INT327031

Context Info Confidence 0.38 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.27 Pain Relevance 0

cytosol (Akt2) transport (Akt2) mitochondrion (Akt2) plasma membrane (Akt2) nucleus (Akt2) carbohydrate metabolic process (Akt2)

Anatomy Link Frequency skin 1 Akt2 (Mus musculus)

Pain Link Frequency Relevance Heat fibrosis 5 5.00 Inflammation 2 5.00 ketamine 1 5.00 anesthesia 1 5.00 withdrawal 1 5.00 dexamethasone 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Muscular Atrophy 2 98.60 Dwarfism 1 97.56 Obesity 2 71.12 Hypertrophy 1 39.20 Injury 10 28.88 Muscular Dystrophy 1 20.56 Muscle Disease 4 14.88 Birth Weight 9 5.00 Fibrosis 5 5.00 Apoptosis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Peng et al. (2003) reported that dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis occurred in mice lacking Akt1 and Akt2.

Negative_regulation (lacking) of Akt2 in skin associated with dwarfism and muscular atrophy

1) Confidence 0.38 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.27 Pain Relevance 0

General Comments

This test has worked.