INT327033

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.38
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor)
endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)
Mtor (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 108 99.84 Very High Very High Very High
Inflammation 4 64.96 Quite High
cerebral cortex 30 53.00 Quite High
fibrosis 10 52.32 Quite High
anesthesia 5 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 105 99.84 Very High Very High Very High
Stress 84 99.50 Very High Very High Very High
Hypoxia 18 98.76 Very High Very High Very High
Muscular Atrophy 4 94.80 High High
Hypertrophy 2 92.20 High High
Obesity 4 76.20 Quite High
Injury 20 70.00 Quite High
INFLAMMATION 4 64.96 Quite High
Dwarfism 2 55.64 Quite High
Fibrosis 10 52.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we found that a submicromolar concentration of As2O3 significantly and dose-dependently decreased phosphorylation of Akt protein and its downstream targets, mTOR and p70s6k, during myogenic differentiation.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of mTOR
1) Confidence 0.07 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.56 Pain Relevance 0.06
As2O3 inhibits phosphorylation of Akt, mTOR (mammalian target of rapamycin), and p70s6k
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of mTOR
2) Confidence 0.07 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0 Pain Relevance 0
In addition, mTOR autophosphorylation at Ser2481 (24) was also decreased by ischemia (data not shown).
Negative_regulation (decreased) of Phosphorylation (autophosphorylation) of mTOR associated with ischemia
3) Confidence 0.05 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.36 Pain Relevance 0.05
We found a significant decrease in Ser473 phosphorylation in ischemic stress that was related to the decreased mTOR phosphorylation at Ser2448.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of mTOR associated with stress
4) Confidence 0.05 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.10 Pain Relevance 0
I15 induced a significant decrease in mTOR phosphorylation at the Ser2448 site, which was restored to control levels upon reperfusion (R30 or R3d), with the exception of CA1 SHC that had increased Ser2448 phosphorylation (Fig. 6; supplemental Fig.
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of mTOR associated with ischemia
5) Confidence 0.03 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.35 Pain Relevance 0.12

General Comments

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