INT32705

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Context Info
Confidence 0.65
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.62
Pain Relevance 4.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp2c12)
Anatomy Link Frequency
liver 3
Cyp2c12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 16 100.00 Very High Very High Very High
narcan 2 100.00 Very High Very High Very High
Paracetamol 33 92.44 High High
Cancer pain 2 79.84 Quite High
Pain 2 74.08 Quite High
carbamazepine 2 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
antiepileptic Drug 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 6 81.44 Quite High
Cancer Pain 2 79.84 Quite High
Pain 2 74.08 Quite High
Aging 22 40.12 Quite Low
Sprains And Strains 2 17.68 Low Low
Toxicity 7 11.32 Low Low
Stress 7 5.00 Very Low Very Low Very Low
Drug-induced Liver Injury 7 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Repression 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The catechol was formed at rates of 2.21 and 0.53 nmol/nmol of P-450/10 min by cytochromes P-450PB-B and P-450 beta NF-B, respectively.
Gene_expression (formed) of P-450
1) Confidence 0.65 Published 1988 Journal Chem. Res. Toxicol. Section Abstract Doc Link 2979711 Disease Relevance 0.08 Pain Relevance 0.56
In contrast to these results, two other constitutive P-450 isozymes from rat liver, cytochrome P-450UT-F and the female specific isozyme P-450UT-I, produced less of both oxidative metabolites.
Gene_expression (produced) of P-450 in liver
2) Confidence 0.65 Published 1988 Journal Chem. Res. Toxicol. Section Abstract Doc Link 2979711 Disease Relevance 0.08 Pain Relevance 0.63
In contrast to these results, two other constitutive P-450 isozymes from rat liver, cytochrome P-450UT-F and the female specific isozyme P-450UT-I, produced less of both oxidative metabolites.
Gene_expression (produced) of P-450 in liver
3) Confidence 0.65 Published 1988 Journal Chem. Res. Toxicol. Section Abstract Doc Link 2979711 Disease Relevance 0.08 Pain Relevance 0.62
In contrast to these results, two other constitutive P-450 isozymes from rat liver, cytochrome P-450UT-F and the female specific isozyme P-450UT-I, produced less of both oxidative metabolites.
Gene_expression (produced) of P-450UT-I in liver
4) Confidence 0.65 Published 1988 Journal Chem. Res. Toxicol. Section Abstract Doc Link 2979711 Disease Relevance 0.08 Pain Relevance 0.61
Principal component 1 (PC1), when ranked by factor loadings, consisted of genes exhibiting high female expression and low male expression (female-specific top genes: Cyp2c12 (cytochrome P450, family 2, subfamily c, polypeptide 12); Akr1b8 (aldo-keto reductase family 1 member b8); Sult2a1 (sulfotransferase family 2a member 1); Prlr (prolactin receptor)).
Gene_expression (expression) of Cyp2c12
5) Confidence 0.41 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0 Pain Relevance 0
Met-Enkephalin was expressed in four nonneuroendocrine cell lines: COS-7, C2C12, Ltk-, and NIH3T3.
Gene_expression (expressed) of C2C12 associated with enkephalin
6) Confidence 0.00 Published 1995 Journal Peptides Section Abstract Doc Link 7479338 Disease Relevance 0.15 Pain Relevance 0.82
Production of bioactive enkephalin from the nonendocrine cell lines COS-7, NIH3T3, Ltk-, and C2C12.
Gene_expression (Production) of C2C12 associated with narcan and enkephalin
7) Confidence 0.00 Published 1995 Journal Peptides Section Title Doc Link 7479338 Disease Relevance 0.15 Pain Relevance 0.87

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